**Educational Content: Antibiotic Binding Sites on Ribosomes**---**Task:**Match the ribosome antibiotics with their binding sites and activities.- **Puromycin** - [Choose]- **Macrolides (azithromycin, i.e., Z-pak)** - [Choose]- **Aminoglycosides (kanamycin)** - [Choose]- **Chloramphenicol** - [Choose] - Binds the 30S subunit at the decoding site, interferes with decoding, leading to misreading and production of incorrect proteins. - Binds the E site and prevents deacylated tRNAs from exiting. This drives the peptidyltransferase activity backwards. - Binds the A site and mimics an aminoacyl-tRNA, is added onto the growing peptide chain by the peptidyltransferase activity. - Binds the peptidyltransferase site and blocks peptidyltransferase activity, may also block the tRNAs from entering the A site.---**Explanation of Binding Effects:**Ribosomal antibiotics affect protein synthesis by binding to specific sites on the ribosome, each causing distinct disruptions:1. **30S Subunit Binding** - Interferes with the decoding process, leading to errors in protein synthesis.2. **E Site Blocking** - Prevents exit of deacylated tRNAs, impacting the recycling of tRNA.3. **A Site Mimicry** - Imitates aminoacyl-tRNA, disrupting the normal transfer of amino acids to the growing peptide chain.4. **Peptidyltransferase Site Blocking** - Inhibits the enzymatic activity that forms peptide bonds between amino acids, critical for protein elongation.Understanding these mechanisms is crucial for pharmacology and microbiology, aiding in the development and implementation of antibiotic treatments.

Match the ribosome antibiotics with their binding sites and activities Puromycin [ Choose ] Macrolides (azithromycin, i.e., Z-pak) [ Choose ] Aminoglycosides (kanamycin) [ Choose ] Chloramphenicol V[ Choose ] Binds the 30S subunit the decoding site, interferes with decoding, leading to mis-reading andproductic Binds the E site and prevents de-acylated tRNAs from exiting. This drives pt'ase activity backwards and Binds the A site and mimics an aa-TRNA, is added onto the growing peptide chain by the pt'ase activity of

Match the ribosome antibiotics with their binding sites and activities Puromycin [ Choose ] Macrolides (azithromycin, i.e., Z-pak) [ Choose ] Aminoglycosides (kanamycin) [ Choose ] Chloramphenicol V[ Choose ] Binds the 30S subunit the decoding site, interferes with decoding, leading to mis-reading andproductic Binds the E site and prevents de-acylated tRNAs from exiting. This drives pt'ase activity backwards and Binds the A site and mimics an aa-TRNA, is added onto the growing peptide chain by the pt'ase activity of

Human Anatomy & Physiology (11th Edition)

11th Edition

ISBN:9780134580999

Author:Elaine N. Marieb, Katja N. Hoehn

Publisher:Elaine N. Marieb, Katja N. Hoehn

Chapter1: The Human Body: An Orientation

Section: Chapter Questions

Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...

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How is the ribosome a target in terms of antibiotic action mechanisms? https://www.youtube.com/watch?v=IVBCrzjOl40
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