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You have mutated Trypsin by replacing Asp 189 in the specificity pocket with Arginine. Which substrates (from the list below) your mutant protease would cleave? Assume that you are cleaving the bond shown in red. RN and Rc-denote the N and the C termini of your protein on either side of the bond. Select ALL that applies: Arg 189. Arg Trypsin D189R mutant RN-Glu---Met-Rc RN-Val---Met-Rc RN-Lys---Met-Rc RN-Phe---Val-Rc RN-Met---Lys-Rc RN-Val---Asp-Rc RN-Asp---Glu-Rc

You have mutated Trypsin by replacing Asp 189 in the specificity pocket with Arginine. Which substrates (from the list below) your mutant protease would cleave? Assume that you are cleaving the bond shown in red. RN and Rc-denote the N and the C termini of your protein on either side of the bond. Select ALL that applies: Arg 189. Arg Trypsin D189R mutant RN-Glu---Met-Rc RN-Val---Met-Rc RN-Lys---Met-Rc RN-Phe---Val-Rc RN-Met---Lys-Rc RN-Val---Asp-Rc RN-Asp---Glu-Rc

Biochemistry
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
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Question 18 ( You have mutated Trypsin by replacing Asp 189 in the specificity pocket with Arginine. Which substrates (from the list below) your mutant protease would cleave? Assume that you are cleaving the bond shown in red. RN and Rc-denote the N and the C termini of your protein on either side of the bond. Select ALL that applies: Arg 189. Arg Trypsin D189R mutant RN-Glu---Met-Rc RN-Val---Met-Rc RN-Lys---Met-Rc RN-Phe---Val-Rc RN-Met---Lys-Rc RN-Val---Asp-Rc RN-Asp---Glu-Rc 00
Transcribed Image Text:Question 18 ( You have mutated Trypsin by replacing Asp 189 in the specificity pocket with Arginine. Which substrates (from the list below) your mutant protease would cleave? Assume that you are cleaving the bond shown in red. RN and Rc-denote the N and the C termini of your protein on either side of the bond. Select ALL that applies: Arg 189. Arg Trypsin D189R mutant RN-Glu---Met-Rc RN-Val---Met-Rc RN-Lys---Met-Rc RN-Phe---Val-Rc RN-Met---Lys-Rc RN-Val---Asp-Rc RN-Asp---Glu-Rc 00
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