Gap FIGURE 24.10 A multiple-sequence 50 alignment for selected members of the globin aj alpha-1 VLSP.'ADKIN VKAAWGKVGA HAGEGAEAL ERMELSFPIT KTYEPHE. DL az alpha-2 VLSP.ADKIN VKAAWGKVGA HAGEGAEAL ERMFLSFPII KIYEPHE. DL gene family in humans. 0 theta ALSA. EDRAL VRALWKKLGS NVGVYTTEAL ERTFLAFPAT KIYFSHL. DL ( zeta SLIK.TERTI IVSMWAKIST QADIIGTETL ERLFLSHPOT KIYEPHE. DL B beta VHLTPEEKSA VIALWGKV.. NVDEVGGEAL GRLLVVYPWT QRFFESFGDL 8 delta VHLTPE EKSA VNALWG KV.. NVDAVGGEAL GRLLVVYPWT ORFFESFGDL YA gamma-A GHFTEEDKAT ITSLWG KV.. NVEDAGGEAL GRLLVVYPWT ORFFESFGDL Ye gamma-G GHFTEEDKAT ITSLWGKV.. NVEDAGGEAL GRLLVV YPWI ORFFESFGDL e epsilon VHFTA EEKAA VISLWS KM.. NVEEAGGEAL GRLLVVYPWT QRFFESFGDL Gap Gap 51 100 aj alpha-1 SHGSA... OVKGHGKKVA DALTNA VAHV DDMPNALSAL SDLHAHKLRV az alpha-2 SHGSA O theta SPGSS S zeta HPGSA. B beta STPDAVMGNP KVKAHGKKVL GAFSDGLAHL DNLKGTFAIL SELHCDKLHV 8 delta SSPDAVMGNP KVKAHGKKVL GAFSDGLAHL DNLKGTFSQL SELHCDKLHV YA gamma-A SSASAIMGNP KVKAHGKKVL TSLGDAIKHL DDLKGIFAQL SELHCDKLHV Ye gamma-G SSASAIMGNP KVKAHGKKVL TSLGDAIKHL DDLKGIFAQL SELHCDKLHV e epsilon SSPSAILGNP KVKAHGKKVL TSFGDAIKNM DNLKPAFAKL SELHCDKLHV QVKGHGKKVA DALINAVAHV DDMPNALSAL SDLHAHKLRV QVKAHGQKVA DALSLAVERL DDLPHALSAL SHLHACOLRV QLRAHGSKVV AAVGDAVKSI DDIGGALSKL SELHAYQLRV 101 148 a, alpha-1 DPVNFKLLSH CLLVILAAHL PAEFTPAVHA SLDKFLASVSs TVLTSKYR az alpha-2 DPVN FKLLSH CLLVILAAHL PAEFTPAVHA SLDKFLASVS TVLISKYR O theta DPASFQLLGH CLLVILARHL PGDFSPALQA SLDKFLSHSVI SALVSEYR ( zeta DPVNFKLLSH CLLVILAARF PADFTAEAHA AWDKFLSVVS SVLTEKYR B beta DPENFRLLGN VLVCVLAHHF GKEFIPPVQA AYQKVVAGVA NALAHKYH 8 delta DPENFR LLGN VLVCVLARNE GKEFTPOMQA AYQKVVAGVA NALAHKYH YA gamma-A DPENFRLLGN VLVCVLAIHF GKEFIPEVQA SWQKMVTAVA SALSSR YH Ye gamma-G DPENFRLLGN VLVCVLAIHF GKEFTPEVQA SWOKMVIAVA SALSSRYH e epsilon DPENFRLLGN VMV IILATHE GKEFTPEVQA AWQKLVSAVA IALAHKYH

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Mitochondrial Mutations

A mitochondrion is a cellular organelle that serves as the site for cellular respiration and energy production (ATP or Adenosine Triphosphate). It is a double-membrane-bound organelle and is only present in eukaryotic cells.