3a) Based on the diagram, in which tissues will the PitX1 gene be expressed? 3b) Assume a fish inherits a deletion mutation in the pituitary switch/enhancer sequence. You isolate DNA from jaw, pelvic, eye, and pituitary tissues. In the DNA of which tissue(s) would you expect to see the pituitary enhancer mutation? Jaw Eye Pelvis Pituitary All of the above 3c) A fish does not produce activator 1 proteins because of a mutation in the gene that encodes those proteins. In which of the following tissues will the Pitx1 gene will be expressed? Select ALL that apply Jaw Pituitary C. Pelvis D. Eye E. None of the tissues
LO: Explain how mutations in regulatory regions of genes differ from mutations in coding region
The presence or absence of pelvic spines in the stickleback fish is controlled by whether the Pitx1 gene is expressed in the pelvic tissue. The Figure below shows how Pitx1 transcription is regulated in different tissues. The center image is that of a stickleback embryo. The drawings in the surrounding boxes show the Pitx1 gene region and activator proteins present in the jaw, pelvis, eye, or pituitary tissues. While the diagram only shows one activator in one tissue, many activators are present in a particular tissue at any one time.
Activator molecules with specific shading can bind to switches with the same shading.
3a) Based on the diagram, in which tissues will the PitX1 gene be expressed?
3b) Assume a fish inherits a deletion mutation in the pituitary switch/enhancer sequence. You isolate DNA from jaw, pelvic, eye, and pituitary tissues. In the DNA of which tissue(s) would you expect to see the pituitary enhancer mutation?
- Jaw
- Eye
- Pelvis
- Pituitary
- All of the above
3c) A fish does not produce activator 1 proteins because of a mutation in the gene that encodes those proteins. In which of the following tissues will the Pitx1 gene will be expressed?
Select ALL that apply
- Jaw Pituitary C. Pelvis D. Eye E. None of the tissues
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