Angiotensin converting enzyme (ACE1) is a key regulatory enzyme in the pathway that regulatesblood pressure. Hypertension is a state where the blood pressure is high.ModificationH3AcH3K9(me2)Rat with enrichment for thismodification(normal or hypertensive)ACE1 expression in rat withmodification(Higher or lower)Activation of ACE1 leads to the constriction of blood vessels and the retention of salt andwater, increased blood volume leading to hypertension.In comparing normal to hypertensive rats, it was determined that there was a difference in thehistone modifications in certain tissues.

Answered: Modification H3Ac H3K9(me2) Rat with…

Human Anatomy & Physiology (11th Edition)

11th Edition

ISBN:9780134580999

Author:Elaine N. Marieb, Katja N. Hoehn

Publisher:Elaine N. Marieb, Katja N. Hoehn

Chapter1: The Human Body: An Orientation

Section: Chapter Questions

Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...

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Angiotensin converting enzyme (ACE1) is a key regulatory enzyme in the pathway that regulates
blood pressure. Hypertension is a state where the blood pressure is high.
Modification
H3Ac
H3K9(me2)
Rat with enrichment for this
modification
(normal or hypertensive)
ACE1 expression in rat with
modification
(Higher or lower)
Activation of ACE1 leads to the constriction of blood vessels and the retention of salt and
water, increased blood volume leading to hypertension.
In comparing normal to hypertensive rats, it was determined that there was a difference in the
histone modifications in certain tissues.

Expert Solution

Step 1

The renin-angiotensin system (RAS) is a hormonal system which control blood pressure, total peripheral resistance and maintain water-electrolytes balance in our body. This RAS has been involved in the progression of hypertension and harm various organs. The parameters of RAS respond differently in case of hypertensive rats as compared to normal rats.

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