12 Nonsense mutationMissense mutationThe most likely of these 5 to beleaky loss of function mutationGain of functionThe most likely of these 5 to causean anormal phenotype inheterozygotes with one copy of themutant allele and one wild typeallele[Choose ][Choose ]✓ [Choose ]41[Choose ] Many "hedgehog" mutants have been recovered in Drosophila melanogaster,which have a phenotype reminiscent of the spiky animal. The hedgehog gene isan important regulator of embryonic development and its human homolog isperturbed in some cancers. A wide variety of mutations have been identified viasequencing of mutant alleles. Five of these are described here:1. hhºK: a point mutation changing amino acid 109 from proline to leucine2. hh¹³C: a point mutation changing a tryptophan codon in the middle of thecoding region to a stop codon3. hhHL2: a two nucleotide deletion in an exon located in the middle of thecoding region4. hh Moonrat: a 24 bp deletion in an enhancer regulating the expression of thegene causing it to be expressed in embryonic cells that normally do not expresshedgehog5. hhGW1: inversion of a portion of the coding regionFrameshift mutationNonsense mutationMissense mutationThe most likely of these 5 to be aJoalaylocs of fu actiontion[Choose ]32541[Choose ][Choose ]

Name: 12 Nonsense mutationMissense mutationThe most likely of these 5 to bel
Uploaded: 2024-03-20T06:42:55.000Z
Channel: Bartleby
Description: 12 Nonsense mutationMissense mutationThe most likely of these 5 to beleaky loss of function mutationGain of functionThe most likely of these 5 to causean anormal phenotype inheterozygotes with one copy of themutant allele and one wild typeallele[Choo