
FUND.OF GEN CHEM CHAP 1-13 W/ACCESS
16th Edition
ISBN: 9781323406038
Author: McMurry
Publisher: PEARSON C
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Question
Chapter 7, Problem 7.50AP
Interpretation Introduction
Interpretation:
The reason for why catalyst does not change the reactants and products at equilibrium has to be explained briefly.
Concept Introduction:
- Reactant: In a chemical reaction the species that present left is denoted as reactant which undergoes chemical change and result to given new species called product.
- Product: In a chemical reaction the species that present in right side is denoted as product that results from the reactant.
- Backward Reaction: This type of reaction process involved a reversible, if the products can be converted into a back to reactants.
- Forward Reaction: This type of reaction has involved irreversible, if obtained product cannot be converted back in to respective reactants under the same conditions.
Chemical equilibrium : The term applied to reversiblechemical reactions . It is the point at which the rate of the forward reaction is equal to the rate of the reverse reaction. The equilibrium is achieved when the concentrations of reactants and products become constant.- Catalyst: The catalyst is a chemical substance that increases the
rate of the reaction without participating in the reaction by reducing the activation energy of the reaction.
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The beta-lactamase hydrolyzes the lactam-ring in penicillin. Describe the mechanism
of hydrolysis, insuring to include the involvement of S, D, & K in the reaction sequence. Please help
To map the active site of beta-lactamase, the enzyme was hydrolyzed with trypsin to yield a hexapeptide (P1) with the following amino acids. Glu, Lys, Leu, Phe, Met, and Ser. Treatment of P1 with phenyl isothiocyanate yielded a PTH derivative of phenylalanine and a peptide (P2). Treatment of P1 with cyanogenbromide gave an acidic tetrapeptide (P3) and a dipeptide (P4).Treatment of P2 with 1-fluoro-2,4-dinitrobenzene, followed by complete hydrolysis, yields N-2,4-dinitrophenyl-Glu. P1, P2, and P3 contain the active site serine.
Why doesn't D in this hexapeptide not participate in the hydrolysis of the beta-lactam ring even though S, K, and D are involved in the catalyst?
To map the active site of -lactamase, the enzyme was hydrolyzed with trypsin to yield a hexapeptide (P1) with the following amino acids. Glu, Lys, Leu, Phe, Met, and Ser. Treatment of P1 with phenyl isothiocyanate yielded a PTH derivative of phenylalanine and a peptide (P2). Treatment of P1 with cyanogenbromide gave an acidic tetrapeptide (P3) and a dipeptide (P4).Treatment of P2 with 1-fluoro-2,4-dinitrobenzene, followed by complete hydrolysis, yields N-2,4-dinitrophenyl-Glu. P1, P2, and P3 contain the active site serine.
Using the experimental results described above derive the primary sequence of the active site hexapeptide. Please help!
Chapter 7 Solutions
FUND.OF GEN CHEM CHAP 1-13 W/ACCESS
Ch. 7.1 - Classify each of the following as having potential...Ch. 7.2 - Based on bond energies, which atmospheric gas in...Ch. 7.3 - Prob. 7.1CIAPCh. 7.3 - How many Calories (i.e., kilocalories) are in a...Ch. 7.3 - Prob. 7.3PCh. 7.3 - Prob. 7.4PCh. 7.3 - Prob. 7.5PCh. 7.3 - Prob. 7.6PCh. 7.4 - Prob. 7.7PCh. 7.4 - Prob. 7.8KCP
Ch. 7.5 - The reaction between iron and oxygen to form rust...Ch. 7.6 - Prob. 7.10PCh. 7.8 - Prob. 7.11PCh. 7.8 - Prob. 7.12PCh. 7.8 - Prob. 7.13PCh. 7.8 - The following diagrams represent two similar...Ch. 7.9 - Prob. 7.3CIAPCh. 7.9 - Prob. 7.4CIAPCh. 7.9 - Is the yield of SO3 at equilibrium favored by a...Ch. 7.9 - Prob. 7.16PCh. 7.9 - Prob. 7.17PCh. 7 - What are the signs of H, S, and G for the...Ch. 7 - Prob. 7.19UKCCh. 7 - Prob. 7.20UKCCh. 7 - Two curves are shown in the following energy...Ch. 7 - Prob. 7.22UKCCh. 7 - Prob. 7.23APCh. 7 - Prob. 7.24APCh. 7 - Prob. 7.25APCh. 7 - Prob. 7.26APCh. 7 - Acetylene (H C C H) is the fuel used in welding...Ch. 7 - Prob. 7.28APCh. 7 - Prob. 7.29APCh. 7 - Prob. 7.30APCh. 7 - Prob. 7.31APCh. 7 - Prob. 7.32APCh. 7 - Prob. 7.33APCh. 7 - Prob. 7.34APCh. 7 - Why are most spontaneous reactions exothermic?Ch. 7 - Prob. 7.36APCh. 7 - Prob. 7.37APCh. 7 - Prob. 7.38APCh. 7 - Prob. 7.39APCh. 7 - Prob. 7.40APCh. 7 - Prob. 7.41APCh. 7 - Prob. 7.42APCh. 7 - Prob. 7.43APCh. 7 - Prob. 7.44APCh. 7 - Prob. 7.45APCh. 7 - Prob. 7.46APCh. 7 - Prob. 7.47APCh. 7 - Prob. 7.48APCh. 7 - What is meant by the term chemical equilibrium?...Ch. 7 - Prob. 7.50APCh. 7 - Prob. 7.51APCh. 7 - Prob. 7.52APCh. 7 - Prob. 7.53APCh. 7 - Prob. 7.54APCh. 7 - Use your answer from Problem 7.53 to calculate the...Ch. 7 - Use your answer from Problem 7.54 to calculate the...Ch. 7 - Prob. 7.57APCh. 7 - Prob. 7.58APCh. 7 - Prob. 7.59APCh. 7 - Prob. 7.60APCh. 7 - Prob. 7.61APCh. 7 - Prob. 7.62APCh. 7 - Prob. 7.63APCh. 7 - Prob. 7.64APCh. 7 - Prob. 7.65APCh. 7 - Prob. 7.66APCh. 7 - For the unbalanced combustion reaction shown, 1...Ch. 7 - Prob. 7.68CPCh. 7 - Prob. 7.69CPCh. 7 - Prob. 7.70CPCh. 7 - Urea is a metabolic waste product that decomposes...Ch. 7 - Prob. 7.72CPCh. 7 - Prob. 7.73CPCh. 7 - Methanol, CH3OH, is used as race car fuel. (a)...Ch. 7 - Prob. 7.75CPCh. 7 - Prob. 7.76CPCh. 7 - Prob. 7.77CPCh. 7 - Prob. 7.78GPCh. 7 - Prob. 7.79GPCh. 7 - Prob. 7.80GP
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