Biological Science
Biological Science
5th Edition
ISBN: 9780321743671
Author: Scott Freeman
Publisher: PEARSON
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Chapter 4, Problem 7TYU
Summary Introduction

To review:

The relation between complementary base pairing in a DNA (deoxyribonucleic acid) and the Chargaff’s rule. Whether this rule applies to RNA (ribonucleotide molecule) or not.

Introduction:

DNA is the genetic material that is present in all living cells. It is in the form of a double helix and contains the information that is inherited by the progeny. The information on DNA is expressed in the form of proteins that carry out the basic functions of all the cells. For translation of the genetic code into proteins, an intermediary molecule called RNA has to be formed.

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Explain the importance of Chargaff's rules and the complementary nature of nucleotide bases.
Which statement correctly explains the chemical basis of Chargaff's rules? Specific purines and specific pyrimidines will always be found opposite each other in the two opposing DNA strands. The double-stranded DNA helix contains phosphodiester bonds linking the nucleotides together. The DNA strands are oriented in an antiparallel direction. Phosphate groups and deoxyribose form the outside backbone of the double stranded DNA molecule. Nucleotides are always composed of a pentose sugar, phosphate, and nitrogenous base.
To create a DNA:RNA hybrid from a short stretch of DNA with the sequence 5'-GGCTAAGTATGCCTAGTAGC-3', design the corresponding RNA sequence. Indicate the sequence in a 5' to 3' manner. What type of helix (A, B or Z) will this double-stranded nucleic acid form?
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