Prescott's Microbiology
Prescott's Microbiology
10th Edition
ISBN: 9781259281594
Author: Joanne Willey, Linda Sherwood Adjunt Professor Lecturer, Christopher J. Woolverton Professor
Publisher: McGraw-Hill Education
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Chapter 39.1, Problem 1MI

What organisms serve as the environmental reservoir for L. pneumophila?

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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine: (a) k, C0, V, and AUC* for the bolus iv data  (b) k, ka, B1, and AUC* for the po data  (c) k, ka, B1, and AUC* for the ip data  (d) relative bioavailability for po vs ip, Fpo/Fip  (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip    MAKE SURE ANSWERS HAVE UNITS if appropriate. SHOW ALL WORK, including equation used, variables used and each step to your solution.
2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0  Note that a µCi is a measure of the amount of radioactivity and hence is a measure of the amount of drug present.  Given that the oral bioavailability of this drug is known to be essentially 100%, estimate the following from this…
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Chapter 39 Solutions

Prescott's Microbiology

Ch. 39.1 - Prob. 3.1RIACh. 39.1 - What is the mechanism by which PTx kills host...Ch. 39.1 - Prob. 3.3RIACh. 39.1 - Describe the streptococcal exotoxins and how they...Ch. 39.1 - Prob. 4.2RIACh. 39.2 - What are the three stages of Lyme disease? What...Ch. 39.2 - Prob. 1RIACh. 39.2 - Prob. 2RIACh. 39.2 - Prob. 3RIACh. 39.2 - Prob. 4RIACh. 39.2 - How does transovarian passage occur?Ch. 39.3 - What are the chief differences between tuberculoid...Ch. 39.3 - How does H. pylori increase the local pH in its...Ch. 39.3 - Prob. 3MICh. 39.3 - Prob. 4MICh. 39.3 - Prob. 5MICh. 39.3 - Prob. 1.1RIACh. 39.3 - Why do you think the slow growth rate of M. leprae...Ch. 39.3 - Prob. 2.1RIACh. 39.3 - Prob. 2.2RIACh. 39.3 - Prob. 2.3RIACh. 39.3 - Prob. 2.4RIACh. 39.3 - Prob. 2.5RIACh. 39.3 - Prob. 3.1RIACh. 39.3 - Prob. 3.2RIACh. 39.3 - What is the difference between S. aureus and MRSA?Ch. 39.3 - Prob. 3.4RIACh. 39.3 - Prob. 3.5RIACh. 39.3 - Prob. 3.6RIACh. 39.4 - How do the neurological effects of botulinum toxin...Ch. 39.4 - To which E. coli class does the strain 0157:H7...Ch. 39.4 - How can Clostridium botulinum cause disease even...Ch. 39.4 - Compare the gastroenteritis caused by Vibrio...Ch. 39.4 - Prob. 2.1RIACh. 39.4 - Compare toxigenic E. coli disease with invasive...Ch. 39.4 - Prob. 2.3RIACh. 39.4 - Prob. 3.1RIACh. 39.4 - Prob. 3.2RIACh. 39.4 - Prob. 3.3RIACh. 39.5 - Prob. 1MICh. 39.5 - Prob. 1RIACh. 39.5 - Prob. 2RIACh. 39.5 - How is ornithosis transmitted?Ch. 39.5 - Prob. 4RIACh. 39.6 - What cells and tissues make up the pseudomembrane?Ch. 39.6 - Prob. 2MICh. 39.6 - Prob. 1RIACh. 39.6 - In both C. difficileassociated disease and...Ch. 39.6 - Prob. 3RIACh. 39 - Describe a typhoid carrier. How does one become a...Ch. 39 - Many consider cholera as the most severe form of...Ch. 39 - Compare the three stages of syphilis and Lyme...Ch. 39 - While many Vibrio cholerae strains are found in...Ch. 39 - The spirochete Borrelia burgdorferi causes Lyme...
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