Prescott's Microbiology
10th Edition
ISBN: 9781259281594
Author: Joanne Willey, Linda Sherwood Adjunt Professor Lecturer, Christopher J. Woolverton Professor
Publisher: McGraw-Hill Education
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Textbook Question
Chapter 39.4, Problem 1.1RIA
How can Clostridium botulinum cause disease even when the bacteria are dead?
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Molecular Biology
A-C components of the question are corresponding to attached image labeled 1.
D component of the question is corresponding to attached image labeled 2.
For a eukaryotic mRNA, the sequences is as follows where AUGrepresents the start codon, the yellow is the Kozak sequence and (XXX) just represents any codonfor an amino acid (no stop codons here). G-cap and polyA tail are not shown
A. How long is the peptide produced?B. What is the function (a sentence) of the UAA highlighted in blue?C. If the sequence highlighted in blue were changed from UAA to UAG, how would that affecttranslation?
D. (1) The sequence highlighted in yellow above is moved to a new position indicated below. Howwould that affect translation? (2) How long would be the protein produced from this new mRNA?
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Explain why the cell doesn’t need 61 tRNAs (one for each codon).
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You discover a disease causing mutation (indicated by the arrow) that alters splicing of its mRNA. This mutation (a base substitution in the splicing sequence) eliminates a 3’ splice site resulting in the inclusion of the second intron (I2) in the final mRNA. We are going to pretend that this intron is short having only 15 nucleotides (most introns are much longer so this is just to make things simple) with the following sequence shown below in bold. The ( ) indicate the reading frames in the exons; the included intron 2 sequences are in bold.
A. Would you expected this change to be harmful? ExplainB. If you were to do gene therapy to fix this problem, briefly explain what type of gene therapy youwould use to correct this.
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Chapter 39 Solutions
Prescott's Microbiology
Ch. 39.1 - What organisms serve as the environmental...Ch. 39.1 - How is the M protein also thought to be involved...Ch. 39.1 - Prob. 3MICh. 39.1 - Why do you think chlamydiae differentiate into...Ch. 39.1 - Compare and contrast the means by which people...Ch. 39.1 - Prob. 1.3RIACh. 39.1 - What are the three major causes of meningitis? Why...Ch. 39.1 - Prob. 2.2RIACh. 39.1 - What is the reason for the complex antibiotic...Ch. 39.1 - How do multidrug-resistant strains of tuberculosis...
Ch. 39.1 - Prob. 3.1RIACh. 39.1 - What is the mechanism by which PTx kills host...Ch. 39.1 - Prob. 3.3RIACh. 39.1 - Describe the streptococcal exotoxins and how they...Ch. 39.1 - Prob. 4.2RIACh. 39.2 - What are the three stages of Lyme disease? What...Ch. 39.2 - Prob. 1RIACh. 39.2 - Prob. 2RIACh. 39.2 - Prob. 3RIACh. 39.2 - Prob. 4RIACh. 39.2 - How does transovarian passage occur?Ch. 39.3 - What are the chief differences between tuberculoid...Ch. 39.3 - How does H. pylori increase the local pH in its...Ch. 39.3 - Prob. 3MICh. 39.3 - Prob. 4MICh. 39.3 - Prob. 5MICh. 39.3 - Prob. 1.1RIACh. 39.3 - Why do you think the slow growth rate of M. leprae...Ch. 39.3 - Prob. 2.1RIACh. 39.3 - Prob. 2.2RIACh. 39.3 - Prob. 2.3RIACh. 39.3 - Prob. 2.4RIACh. 39.3 - Prob. 2.5RIACh. 39.3 - Prob. 3.1RIACh. 39.3 - Prob. 3.2RIACh. 39.3 - What is the difference between S. aureus and MRSA?Ch. 39.3 - Prob. 3.4RIACh. 39.3 - Prob. 3.5RIACh. 39.3 - Prob. 3.6RIACh. 39.4 - How do the neurological effects of botulinum toxin...Ch. 39.4 - To which E. coli class does the strain 0157:H7...Ch. 39.4 - How can Clostridium botulinum cause disease even...Ch. 39.4 - Compare the gastroenteritis caused by Vibrio...Ch. 39.4 - Prob. 2.1RIACh. 39.4 - Compare toxigenic E. coli disease with invasive...Ch. 39.4 - Prob. 2.3RIACh. 39.4 - Prob. 3.1RIACh. 39.4 - Prob. 3.2RIACh. 39.4 - Prob. 3.3RIACh. 39.5 - Prob. 1MICh. 39.5 - Prob. 1RIACh. 39.5 - Prob. 2RIACh. 39.5 - How is ornithosis transmitted?Ch. 39.5 - Prob. 4RIACh. 39.6 - What cells and tissues make up the pseudomembrane?Ch. 39.6 - Prob. 2MICh. 39.6 - Prob. 1RIACh. 39.6 - In both C. difficileassociated disease and...Ch. 39.6 - Prob. 3RIACh. 39 - Describe a typhoid carrier. How does one become a...Ch. 39 - Many consider cholera as the most severe form of...Ch. 39 - Compare the three stages of syphilis and Lyme...Ch. 39 - While many Vibrio cholerae strains are found in...Ch. 39 - The spirochete Borrelia burgdorferi causes Lyme...
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