Organic Chemistry
Organic Chemistry
9th Edition
ISBN: 9781305080485
Author: John E. McMurry
Publisher: Cengage Learning
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Chapter 31.SE, Problem 18MP
Interpretation Introduction

Interpretation:

Propose the mechanism for the formation of polymeric resin by the reaction of polystyrene with n-(hydroxymethyl) pthalimide and triflouromethanesulphonic acid followed by the reaction with hydrazine.

Concept introduction:

In the Merrifield solid-phase method, peptide synthesis is carried out with the growing amino acid chain covalently bonded to small beads of a polymer resin, rather than in solution.

SN2 reaction is a type of reaction mechanism in which one bond is broken and one bond is formed simultaneously. In first step nucleophilic substitution reaction takes place. Since two reacting species are involved in the slow (rate-determining) step, this leads to the term substitution nucleophilic (bi-molecular) or SN2.

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