The different covalently modified forms of acetyl-CoA carboxylase protein that are possible if there are seven phosphorylation sites needs to be determined. Concept Introduction: Acetyl-CoA carboxylase is the enzyme which is biotin-dependent that is used to catalyze the irreversible carboxylation of the acetyl CoA to yield malonyl-CoA by its 2 catalytic actions, carboxyltransferase and biotin carboxylase.

Question

M-CSA Mechanism and Catalytic Site Atlas (ebi.ac.uk) (ii) Acyl Carrier Protein S-acetyltransferase (EC 2.3.1.38) is a transferase enzyme that catalyzes the first biosynthetic pathway for fatty acid synthase. It transfers the acyl group (CH3CO) first from coenzyme A to a cysteine residue in the active site. This is similar to what happens in Chymotrypsin, however utilizing a sulfur instead of an oxygen. The acyl group is then transferred to the molecule ACP. Provide the enzyme- catalyzed mechanism for the reaction below, making sure to identify the roles of all key amino acids: i H3C SCOA acetyl COA enzyme + HS i H3C SACP acetyl ACP

Answer 1

Question

Chapter 31, Problem 6P

Interpretation Introduction

Interpretation:

The different covalently modified forms of acetyl-CoA carboxylase protein that are possible if there are seven phosphorylation sites needs to be determined.

Concept Introduction:

Acetyl-CoA carboxylase is the enzyme which is biotin-dependent that is used to catalyze the irreversible carboxylation of the acetyl CoA to yield malonyl-CoA by its 2 catalytic actions, carboxyltransferase and biotin carboxylase.

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