Biochemistry
6th Edition
ISBN: 9781305577206
Author: Reginald H. Garrett, Charles M. Grisham
Publisher: Cengage Learning
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Chapter 31, Problem 19P
Interpretation Introduction
Interpretation:
The affect on the half-life of the protein in the removal of Met needs to be explained.
Concept Introduction :
The enzymatic and covalent modification of the proteins during its biosynthesis are known as Post-Translational modification (PTM). The synthesis of protein takes place by the translating the ribosomes from mRNA to polypeptide chains. This results in the formation of a mature protein.
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AAAGAGAAAAGAAUA
to AAAGAGAAAUGAAUA.
Suppose the codon sequence
has a single base pair mutation
If the old protein sequence was Lys-Glu-Lys-Arg-Ile, what will be the new sequence encoded by the mutant gene?
(Use the 3-letter amino acid abbreviations with hyphens and no spaces in between, i.e. Ser-Asn-Tyr-Leu-Pro.)
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Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biochemistry and related others by exploring similar questions and additional content below.Similar questions
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- 4arrow_forwardWhich statements are true? Explain why or why not.1 The consequences of errors in transcription areless severe than those of errors in DNA replication.2 Since introns are largely genetic “junk,” they do nothave to be removed precisely from the primary transcriptduring RNA splicing.3 Wobble pairing occurs between the first positionin the codon and the third position in the anticodon.4 During protein synthesis, the thermodynamics ofbase-pairing between tRNAs and mRNAs sets the upperlimit for the accuracy with which protein molecules aremade.5 Protein enzymes are thought to greatly outnum-ber ribozymes in modern cells because they can catalyzea much greater variety of reactions and all of them havefaster rates than any ribozyme.arrow_forwardEffect of DNA Mutations on Protein Structure & Function The structure of a typical human protein coding MRNA including the untranslated regions (UTRS) Cap 5' UTR Coding sequence (CDS) Poly-A tail 3' UTR Start Stop 5' 3' Question 2: Which of the following mutations may affect translation initiation? A. Silent mutation in the coding sequence. B. Missense mutation in the coding sequence C. Deletion of four bases in the 5'-UTR D. Deletion of four bases in the 3'-UTRarrow_forward
- Determining the amino acid sequence in a protein usually in- volves treating the protein with various reagents that break up the protein into smaller fragments that can be individually sequenced. Treating a particular 11-amino acid polypeptide with one reagent produced the fragments: Ala-Leu-Phe-Gly-Asn-Lys Trp-Glu-Cys Gly-Arg Treating the same polypeptide with a different reagent pro- duced the fragments: Glu-Cys Gly-Asn-Lys-Trp Gly-Arg-Ala-Leu-Phe What is the amino acid sequence of the polypeptide?arrow_forwardI need help with #28 And #34 thank youarrow_forwardKeeping in mind the circular genome of Mitochondria identify the non-coding regulatory region in Mitochondria. What is its translational status? What regulatory function it performs?arrow_forward
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