Genetic Analysis: An Integrated Approach (2nd Edition)
Genetic Analysis: An Integrated Approach (2nd Edition)
2nd Edition
ISBN: 9780321948908
Author: Mark F. Sanders, John L. Bowman
Publisher: PEARSON
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Chapter 3, Problem 21P

Use the blank pedigrees provided to depict transmission of (a) an X-linked recessive trait and (b) an X-linked dominant trait, by filling in circles and squares to represent individuals with the trait of interest. Give genotypes for each person in each pedigree. Carefully design each transmission pattern so that pedigree (a) cannot be confused with autosomal recessive transmission and pedigree (b) cannot be confused with autosomal dominant transmission. Identify the transmission events that eliminate the possibility of autosomal transmission for each pedigree.

Chapter 3, Problem 21P, 21. Use the blank pedigrees provided to depict transmission of (a) an X-linked recessive trait and

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Cystic fibrosis (CF) is an autosomal recessive trait. A three-generation pedigree is shown below for a family that carries the mutant allele for cystic fibrosis. Note that carriers are not colored in to allow you to figure out their genotypes.      Normal allele =  F      CF mutant allele =  f        What is the genotype of individual #13? A) ff B) FF C) Ff  D) it is impossible to tell
A young woman is worried about having a child because her mother's only sister had a son with Duchenne muscular dystrophy (DMD). The young woman has no brothers or sisters. (DMD is a rare X-linked recessive disorder.) (a)Draw the relevant parts of the pedigree of the family described above. Be sure to include the grandmother, the other three women mentioned, and all their spouses. Fill in genotypes according to the information in hand.  (b)Calculate the probability that the young woman's first child will have DMD.
The following pedigree shows the inheritance of a human disorder. Affected individuals are shown with filled symbols. II III 2 3 5 Based on the pedigree, propose the least likely inheritance pattern of the disease among autosomal dominance, autosomal recessive, X-linked dominance and X-linked recessive. Your choice of answer can be impossible and possible. Explain your answer by giving the evidence that supports or opposes each mode of inheritance. You can reconstruct the table shown below and draw the pedigree in your answer script. Write the possible genotype of each individual in the pedigree for each inheritance pattern proposed. Mode of Possibility Explanations Pedigree inheritance Autosomal dominance Autosomal recessive X-linked dominance X-linked recessive

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Genetic Analysis: An Integrated Approach (2nd Edition)

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