Genetic Analysis: An Integrated Approach (2nd Edition)
Genetic Analysis: An Integrated Approach (2nd Edition)
2nd Edition
ISBN: 9780321948908
Author: Mark F. Sanders, John L. Bowman
Publisher: PEARSON
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Chapter 3, Problem 31P

While examining a young tortoiseshell cat, you and the veterinarian you are interning with get a surprise - the cat is male, not female ! from your undergraduate genetics course, you recall that tortoiseshell coats are produced by the random X - inactivation that takes place in mammalian females. The veterinarian orders a chromosome analysis of the cat and finds that he is XXX : He has two X chromosomes and one Y chromosome. Help the veterinarian figure out how a tortoiseshell cat could be male. (Hint : Think about X - inactivation in mammals with two X chromosomes.)

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Cat fur coat color genetics is interesting. Orange fur is dominant (''B'') to black fur (''b'') and piebald, which is white spotting, is dominant (''S'') to non-white-spotted (''s''). Both of those genes are located on the X chromosome. In addition, in cats, somatic cells exhibit X-inactivation randomly, which explains why there are tortoiseshell cats (when heterozygous, have orange and black spots) as well as calico cats (orange and black but also with white spots). An orange and white spotted male is mated with a tortoiseshell female. State the genotype of the male and the female.
Cat fur coat color genetics is interesting. Orange fur is dominant (''B'') to black fur (''b'') and piebald, which is white spotting, is dominant (''S'') to non-white-spotted (''s''). Both of those genes are located on the X chromosome. In addition, in cats, somatic cells exhibit X-inactivation randomly, which explains why there are tortoiseshell cats (when heterozygous, have orange and black spots) as well as calico cats (orange and black but also with white spots). An orange and white spotted male is mated with a tortoiseshell female. Draw a dihybrid Punnet square to show the possible offspring:
Although most tortoiseshell cats are female, a litter of kittens will occasionally contain a male tortoiseshell. Which of the following can explain tortoiseshell coat color in a male kitten? Please explain in detail. The male kitten has an extra Y chromosome The male kitten has an extra X chromosome The male kitten has no X chromosome The male kitten cannot carry out X-inactivation

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Genetic Analysis: An Integrated Approach (2nd Edition)

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