(a) Interpretation: Whether the peptides which have an amino-terminal acetyl group can undergo the Edman degradation or not is to be explained. Concept introduction: The Edman degradation is a process to identify the amino acid sequence in a peptide. In this process, the residue of amino-terminal is labeled and cleaved from peptide and the other peptide bonds present between the other amino acid residues do not get disturbed. The reaction is helpful for the N - terminal peptide.

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Answer 1

Question

Chapter 27, Problem 27.30P

Interpretation Introduction

(a)

Interpretation:

Whether the peptides which have an amino-terminal acetyl group can undergo the Edman degradation or not is to be explained.

Concept introduction:

The Edman degradation is a process to identify the amino acid sequence in a peptide. In this process, the residue of amino-terminal is labeled and cleaved from peptide and the other peptide bonds present between the other amino acid residues do not get disturbed.

The reaction is helpful for the N- terminal peptide.

Interpretation Introduction

(b)

Interpretation:

Whether the N- acylation have any adverse effect on sequencing by MS−MS or not is to be stated with explanation.

Concept introduction:

In mass spectroscopy, compounds can be identified on the basis of mass of compound. When the compound breaks into fragment then they can be distinguished from the other compounds. This technique is also used to differentiate the isotopes of compounds. This technique did not interact with electromagnetic radiation. Two peaks are used to identify the compound, first, the molecular ion peak which is the mass of the compound and second, the base peak which is the most abundant element peak. It may be same or different.

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6. Consider the following exothermic reaction below. 2Cu2+(aq) +41 (aq)2Cul(s) + 12(aq) a. If Cul is added, there will be a shift left/shift right/no shift (circle one). b. If Cu2+ is added, there will be a shift left/shift right/no shift (circle one). c. If a solution of AgNO3 is added, there will be a shift left/shift right/no shift (circle one). d. If the solvent hexane (C6H14) is added, there will be a shift left/shift right/no shift (circle one). Hint: one of the reaction species is more soluble in hexane than in water. e. If the reaction is cooled, there will be a shift left/shift right/no shift (circle one). f. Which of the changes above will change the equilibrium constant, K?

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Answer 2

Question

Chapter 27, Problem 27.30P

Interpretation Introduction

(a)

Interpretation:

Whether the peptides which have an amino-terminal acetyl group can undergo the Edman degradation or not is to be explained.

Concept introduction:

The Edman degradation is a process to identify the amino acid sequence in a peptide. In this process, the residue of amino-terminal is labeled and cleaved from peptide and the other peptide bonds present between the other amino acid residues do not get disturbed.

The reaction is helpful for the N- terminal peptide.

Interpretation Introduction

(b)

Interpretation:

Whether the N- acylation have any adverse effect on sequencing by MS−MS or not is to be stated with explanation.

Concept introduction:

In mass spectroscopy, compounds can be identified on the basis of mass of compound. When the compound breaks into fragment then they can be distinguished from the other compounds. This technique is also used to differentiate the isotopes of compounds. This technique did not interact with electromagnetic radiation. Two peaks are used to identify the compound, first, the molecular ion peak which is the mass of the compound and second, the base peak which is the most abundant element peak. It may be same or different.

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Answer 3

Question

Chapter 27, Problem 27.30P

Interpretation Introduction

(a)

Interpretation:

Whether the peptides which have an amino-terminal acetyl group can undergo the Edman degradation or not is to be explained.

Concept introduction:

The Edman degradation is a process to identify the amino acid sequence in a peptide. In this process, the residue of amino-terminal is labeled and cleaved from peptide and the other peptide bonds present between the other amino acid residues do not get disturbed.

The reaction is helpful for the N- terminal peptide.

Interpretation Introduction

(b)

Interpretation:

Whether the N- acylation have any adverse effect on sequencing by MS−MS or not is to be stated with explanation.

Concept introduction:

In mass spectroscopy, compounds can be identified on the basis of mass of compound. When the compound breaks into fragment then they can be distinguished from the other compounds. This technique is also used to differentiate the isotopes of compounds. This technique did not interact with electromagnetic radiation. Two peaks are used to identify the compound, first, the molecular ion peak which is the mass of the compound and second, the base peak which is the most abundant element peak. It may be same or different.

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Answer 4

Question

Chapter 27, Problem 27.30P

Interpretation Introduction

(a)

Interpretation:

Whether the peptides which have an amino-terminal acetyl group can undergo the Edman degradation or not is to be explained.

Concept introduction:

The Edman degradation is a process to identify the amino acid sequence in a peptide. In this process, the residue of amino-terminal is labeled and cleaved from peptide and the other peptide bonds present between the other amino acid residues do not get disturbed.

The reaction is helpful for the N- terminal peptide.

Interpretation Introduction

(b)

Interpretation:

Whether the N- acylation have any adverse effect on sequencing by MS−MS or not is to be stated with explanation.

Concept introduction:

In mass spectroscopy, compounds can be identified on the basis of mass of compound. When the compound breaks into fragment then they can be distinguished from the other compounds. This technique is also used to differentiate the isotopes of compounds. This technique did not interact with electromagnetic radiation. Two peaks are used to identify the compound, first, the molecular ion peak which is the mass of the compound and second, the base peak which is the most abundant element peak. It may be same or different.

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Answer 5

Chapter 27, Problem 27.30P

Interpretation Introduction

(a)

Interpretation:

Whether the peptides which have an amino-terminal acetyl group can undergo the Edman degradation or not is to be explained.

Concept introduction:

The Edman degradation is a process to identify the amino acid sequence in a peptide. In this process, the residue of amino-terminal is labeled and cleaved from peptide and the other peptide bonds present between the other amino acid residues do not get disturbed.

The reaction is helpful for the N- terminal peptide.

Interpretation Introduction

(b)

Interpretation:

Whether the N- acylation have any adverse effect on sequencing by MS−MS or not is to be stated with explanation.

Concept introduction:

In mass spectroscopy, compounds can be identified on the basis of mass of compound. When the compound breaks into fragment then they can be distinguished from the other compounds. This technique is also used to differentiate the isotopes of compounds. This technique did not interact with electromagnetic radiation. Two peaks are used to identify the compound, first, the molecular ion peak which is the mass of the compound and second, the base peak which is the most abundant element peak. It may be same or different.

Answer 6

Chapter 27, Problem 27.30P

Interpretation Introduction

(a)

Interpretation:

Whether the peptides which have an amino-terminal acetyl group can undergo the Edman degradation or not is to be explained.

Concept introduction:

The Edman degradation is a process to identify the amino acid sequence in a peptide. In this process, the residue of amino-terminal is labeled and cleaved from peptide and the other peptide bonds present between the other amino acid residues do not get disturbed.

The reaction is helpful for the N- terminal peptide.

Answer 7

Chapter 27, Problem 27.30P

Interpretation Introduction

(a)

Interpretation:

Whether the peptides which have an amino-terminal acetyl group can undergo the Edman degradation or not is to be explained.

Concept introduction:

The Edman degradation is a process to identify the amino acid sequence in a peptide. In this process, the residue of amino-terminal is labeled and cleaved from peptide and the other peptide bonds present between the other amino acid residues do not get disturbed.

The reaction is helpful for the N- terminal peptide.

Answer 8

Interpretation Introduction

(b)

Interpretation:

Whether the N- acylation have any adverse effect on sequencing by MS−MS or not is to be stated with explanation.

Concept introduction:

In mass spectroscopy, compounds can be identified on the basis of mass of compound. When the compound breaks into fragment then they can be distinguished from the other compounds. This technique is also used to differentiate the isotopes of compounds. This technique did not interact with electromagnetic radiation. Two peaks are used to identify the compound, first, the molecular ion peak which is the mass of the compound and second, the base peak which is the most abundant element peak. It may be same or different.

Answer 9

Interpretation Introduction

(b)

Interpretation:

Whether the N- acylation have any adverse effect on sequencing by MS−MS or not is to be stated with explanation.

Concept introduction:

In mass spectroscopy, compounds can be identified on the basis of mass of compound. When the compound breaks into fragment then they can be distinguished from the other compounds. This technique is also used to differentiate the isotopes of compounds. This technique did not interact with electromagnetic radiation. Two peaks are used to identify the compound, first, the molecular ion peak which is the mass of the compound and second, the base peak which is the most abundant element peak. It may be same or different.

Answer 10

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Answer 11

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Answer 12

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Answer 13

Ch. 27 - Prob. 27.1P Ch. 27 - Prob. 27.2P Ch. 27 - Prob. 27.3P Ch. 27 - Prob. 27.4P Ch. 27 - Prob. 27.5P Ch. 27 - Prob. 27.6P Ch. 27 - Prob. 27.8P Ch. 27 - Prob. 27.9P Ch. 27 - Prob. 27.10P Ch. 27 - Prob. 27.11P

Solution Summary: The author explains that peptides with an amino-terminal acetyl group do not undergo the Edman degradation because the lone pairs of the nitrogen are in conjugation with the carbon-oxygen double bond

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