(a) Interpretation: The reason as to why the two protecting groups used for lysine in the synthesis of the peptide Gly − Lys − Ala using the solid-phase method is to be stated. Concept introduction: Solid-phase peptide synthesis is a technique that is used for peptide synthesis. The peptide is synthesis from C-terminal to N-terminal. It is reverse in biological cells. In this amino protected amino acid is bound covalently on solid phase material with an ester or amide linkage. Then it is deprotected and reacts with another amino protected amino acid. This cycle continues until the desired peptide is not obtained.

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Answer 1

Question

Chapter 27, Problem 27.18P

Interpretation Introduction

(a)

Interpretation:

The reason as to why the two protecting groups used for lysine in the synthesis of the peptide Gly−Lys−Ala using the solid-phase method is to be stated.

Concept introduction:

Solid-phase peptide synthesis is a technique that is used for peptide synthesis. The peptide is synthesis from C-terminal to N-terminal. It is reverse in biological cells. In this amino protected amino acid is bound covalently on solid phase material with an ester or amide linkage. Then it is deprotected and reacts with another amino protected amino acid. This cycle continues until the desired peptide is not obtained.

Interpretation Introduction

(b)

Interpretation:

The structure of each compound obtained from the coupling and decoupling of resin-bound peptide with their explanation is to be stated.

Concept introduction:

Solid-phase peptide synthesis is a technique that is used for peptide synthesis. The peptide is synthesis from C-terminal to N-terminal. It is reverse in biological cells. In this amino protected amino acid is bound covalently on solid phase material with an ester or amide linkage. Then it is deprotected and reacts with another amino protected amino acid. This cycle continues until the desired peptide is not obtained.

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Students have asked these similar questions

Treatment of a new protein with dansyl chloride reveals two (2) dansyl-labelled derivatives of amino acids, alanine and methionine. What can you deduce about the structure of the proteinfrom these results?

In a variation of the Merrifield solid-phase peptide synthesis, the amino group is protected by a fluorenylmethoxycarbonyl (FMOC) group. This protecting group is removed by treatment with a weak base such as the secondary amine piperidine. Write a balanced equation and propose a mechanism for this deprotection.

The amino acid (S)-alanine has the physical characteristics listed under the structure. Label each of the following as optically active or inactive: a solution of pure (S)- alanine; an equal mixture of (R)- and (S)-alanine; a solution that contains 75% (S)- and 25% (R)-alanine.

Answer 2

Question

Chapter 27, Problem 27.18P

Interpretation Introduction

(a)

Interpretation:

The reason as to why the two protecting groups used for lysine in the synthesis of the peptide Gly−Lys−Ala using the solid-phase method is to be stated.

Concept introduction:

Solid-phase peptide synthesis is a technique that is used for peptide synthesis. The peptide is synthesis from C-terminal to N-terminal. It is reverse in biological cells. In this amino protected amino acid is bound covalently on solid phase material with an ester or amide linkage. Then it is deprotected and reacts with another amino protected amino acid. This cycle continues until the desired peptide is not obtained.

Interpretation Introduction

(b)

Interpretation:

The structure of each compound obtained from the coupling and decoupling of resin-bound peptide with their explanation is to be stated.

Concept introduction:

Solid-phase peptide synthesis is a technique that is used for peptide synthesis. The peptide is synthesis from C-terminal to N-terminal. It is reverse in biological cells. In this amino protected amino acid is bound covalently on solid phase material with an ester or amide linkage. Then it is deprotected and reacts with another amino protected amino acid. This cycle continues until the desired peptide is not obtained.

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Answer 3

Question

Chapter 27, Problem 27.18P

Interpretation Introduction

(a)

Interpretation:

The reason as to why the two protecting groups used for lysine in the synthesis of the peptide Gly−Lys−Ala using the solid-phase method is to be stated.

Concept introduction:

Solid-phase peptide synthesis is a technique that is used for peptide synthesis. The peptide is synthesis from C-terminal to N-terminal. It is reverse in biological cells. In this amino protected amino acid is bound covalently on solid phase material with an ester or amide linkage. Then it is deprotected and reacts with another amino protected amino acid. This cycle continues until the desired peptide is not obtained.

Interpretation Introduction

(b)

Interpretation:

The structure of each compound obtained from the coupling and decoupling of resin-bound peptide with their explanation is to be stated.

Concept introduction:

Solid-phase peptide synthesis is a technique that is used for peptide synthesis. The peptide is synthesis from C-terminal to N-terminal. It is reverse in biological cells. In this amino protected amino acid is bound covalently on solid phase material with an ester or amide linkage. Then it is deprotected and reacts with another amino protected amino acid. This cycle continues until the desired peptide is not obtained.

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Answer 4

Question

Chapter 27, Problem 27.18P

Interpretation Introduction

(a)

Interpretation:

The reason as to why the two protecting groups used for lysine in the synthesis of the peptide Gly−Lys−Ala using the solid-phase method is to be stated.

Concept introduction:

Solid-phase peptide synthesis is a technique that is used for peptide synthesis. The peptide is synthesis from C-terminal to N-terminal. It is reverse in biological cells. In this amino protected amino acid is bound covalently on solid phase material with an ester or amide linkage. Then it is deprotected and reacts with another amino protected amino acid. This cycle continues until the desired peptide is not obtained.

Interpretation Introduction

(b)

Interpretation:

The structure of each compound obtained from the coupling and decoupling of resin-bound peptide with their explanation is to be stated.

Concept introduction:

Solid-phase peptide synthesis is a technique that is used for peptide synthesis. The peptide is synthesis from C-terminal to N-terminal. It is reverse in biological cells. In this amino protected amino acid is bound covalently on solid phase material with an ester or amide linkage. Then it is deprotected and reacts with another amino protected amino acid. This cycle continues until the desired peptide is not obtained.

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Answer 5

Chapter 27, Problem 27.18P

Interpretation Introduction

(a)

Interpretation:

The reason as to why the two protecting groups used for lysine in the synthesis of the peptide Gly−Lys−Ala using the solid-phase method is to be stated.

Concept introduction:

Solid-phase peptide synthesis is a technique that is used for peptide synthesis. The peptide is synthesis from C-terminal to N-terminal. It is reverse in biological cells. In this amino protected amino acid is bound covalently on solid phase material with an ester or amide linkage. Then it is deprotected and reacts with another amino protected amino acid. This cycle continues until the desired peptide is not obtained.

Interpretation Introduction

(b)

Interpretation:

The structure of each compound obtained from the coupling and decoupling of resin-bound peptide with their explanation is to be stated.

Concept introduction:

Solid-phase peptide synthesis is a technique that is used for peptide synthesis. The peptide is synthesis from C-terminal to N-terminal. It is reverse in biological cells. In this amino protected amino acid is bound covalently on solid phase material with an ester or amide linkage. Then it is deprotected and reacts with another amino protected amino acid. This cycle continues until the desired peptide is not obtained.

Answer 6

Chapter 27, Problem 27.18P

Interpretation Introduction

(a)

Interpretation:

The reason as to why the two protecting groups used for lysine in the synthesis of the peptide Gly−Lys−Ala using the solid-phase method is to be stated.

Concept introduction:

Solid-phase peptide synthesis is a technique that is used for peptide synthesis. The peptide is synthesis from C-terminal to N-terminal. It is reverse in biological cells. In this amino protected amino acid is bound covalently on solid phase material with an ester or amide linkage. Then it is deprotected and reacts with another amino protected amino acid. This cycle continues until the desired peptide is not obtained.

Answer 7

Chapter 27, Problem 27.18P

Interpretation Introduction

(a)

Interpretation:

The reason as to why the two protecting groups used for lysine in the synthesis of the peptide Gly−Lys−Ala using the solid-phase method is to be stated.

Concept introduction:

Solid-phase peptide synthesis is a technique that is used for peptide synthesis. The peptide is synthesis from C-terminal to N-terminal. It is reverse in biological cells. In this amino protected amino acid is bound covalently on solid phase material with an ester or amide linkage. Then it is deprotected and reacts with another amino protected amino acid. This cycle continues until the desired peptide is not obtained.

Answer 8

Interpretation Introduction

(b)

Interpretation:

The structure of each compound obtained from the coupling and decoupling of resin-bound peptide with their explanation is to be stated.

Concept introduction:

Solid-phase peptide synthesis is a technique that is used for peptide synthesis. The peptide is synthesis from C-terminal to N-terminal. It is reverse in biological cells. In this amino protected amino acid is bound covalently on solid phase material with an ester or amide linkage. Then it is deprotected and reacts with another amino protected amino acid. This cycle continues until the desired peptide is not obtained.

Answer 9

Interpretation Introduction

(b)

Interpretation:

The structure of each compound obtained from the coupling and decoupling of resin-bound peptide with their explanation is to be stated.

Concept introduction:

Solid-phase peptide synthesis is a technique that is used for peptide synthesis. The peptide is synthesis from C-terminal to N-terminal. It is reverse in biological cells. In this amino protected amino acid is bound covalently on solid phase material with an ester or amide linkage. Then it is deprotected and reacts with another amino protected amino acid. This cycle continues until the desired peptide is not obtained.

Answer 10

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Answer 11

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Answer 12

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Answer 13

Ch. 27 - Prob. 27.1P Ch. 27 - Prob. 27.2P Ch. 27 - Prob. 27.3P Ch. 27 - Prob. 27.4P Ch. 27 - Prob. 27.5P Ch. 27 - Prob. 27.6P Ch. 27 - Prob. 27.8P Ch. 27 - Prob. 27.9P Ch. 27 - Prob. 27.10P Ch. 27 - Prob. 27.11P

Solution Summary: The author explains solid-phase peptide synthesis, wherein lysine is protected from both the amine and carboxyl groups.

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Chapter 27 Solutions