(a) Interpretation: The structure of each compound involved in the given solid peptide phase synthesis is to be stated. Concept introduction: Solid phase peptide synthesis is a process in which an amino protected amino acid is treated with insoluble resin. After that, the amino acid is deprotected which gives rise to the formation of a dipeptide. This dipeptide is again treated with the amino protected amino acid. This cycle is repeated several times and resin is removed by using trifluoroacetic acid.

Question

Want to see the full answer?

Answer 1

Question

Chapter 27, Problem 27.19P

Interpretation Introduction

(a)

Interpretation:

The structure of each compound involved in the given solid peptide phase synthesis is to be stated.

Concept introduction:

Solid phase peptide synthesis is a process in which an amino protected amino acid is treated with insoluble resin. After that, the amino acid is deprotected which gives rise to the formation of a dipeptide. This dipeptide is again treated with the amino protected amino acid. This cycle is repeated several times and resin is removed by using trifluoroacetic acid.

Interpretation Introduction

(b)

Interpretation:

A reason as to why Boc group is used on the side chain of the Lys group in the B→C step of the reaction is to be stated.

Concept introduction:

Solid peptide phase synthesis is a process in which an amino protected amino acid is treated with insoluble resin. After that, the amino acid is deprotected which give rise to the formation of a dipeptide. This dipeptide is again treated with an amino protected amino acid. This cycle is repeated several times and resin is removed by using trifluoroacetic acid.

Interpretation Introduction

(c)

Interpretation:

An explanation as to why Boc-Val is used rather than Fmoc-Val in the D→E step of the reaction is to be stated.

Concept introduction:

Solid peptide phase synthesis is a process in which an amino protected amino acid is treated with insoluble resin. After that, the amino acid is deprotected which give rise to the formation of a dipeptide. This dipeptide is again treated with an amino protected amino acid. This cycle is repeated several times and resin is removed by using trifluoroacetic acid.

Expert Solution & Answer

Want to see the full answer?

Check out a sample textbook solution

See solution

Students have asked these similar questions

Highlight each glycosidic bond in the molecule below. Then answer the questions in the table under the drawing area. HO- HO- -0 OH OH HO NG HO- HO- OH OH OH OH NG OH

€ + Suppose the molecule in the drawing area below were reacted with H₂ over a platinum catalyst. Edit the molecule to show what would happen to it. That is, turn it into the product of the reaction. Also, write the name of the product molecule under the drawing area. Name: ☐ H C=0 X H- OH HO- H HO- -H CH₂OH ×

Draw the Haworth projection of the disaccharide made by joining D-glucose and D-mannose with a ẞ(1-4) glycosidic bond. If the disaccharide has more than one anomer, you can draw any of them. Click and drag to start drawing a structure. X

Answer 2

Question

Chapter 27, Problem 27.19P

Interpretation Introduction

(a)

Interpretation:

The structure of each compound involved in the given solid peptide phase synthesis is to be stated.

Concept introduction:

Solid phase peptide synthesis is a process in which an amino protected amino acid is treated with insoluble resin. After that, the amino acid is deprotected which gives rise to the formation of a dipeptide. This dipeptide is again treated with the amino protected amino acid. This cycle is repeated several times and resin is removed by using trifluoroacetic acid.

Interpretation Introduction

(b)

Interpretation:

A reason as to why Boc group is used on the side chain of the Lys group in the B→C step of the reaction is to be stated.

Concept introduction:

Solid peptide phase synthesis is a process in which an amino protected amino acid is treated with insoluble resin. After that, the amino acid is deprotected which give rise to the formation of a dipeptide. This dipeptide is again treated with an amino protected amino acid. This cycle is repeated several times and resin is removed by using trifluoroacetic acid.

Interpretation Introduction

(c)

Interpretation:

An explanation as to why Boc-Val is used rather than Fmoc-Val in the D→E step of the reaction is to be stated.

Concept introduction:

Solid peptide phase synthesis is a process in which an amino protected amino acid is treated with insoluble resin. After that, the amino acid is deprotected which give rise to the formation of a dipeptide. This dipeptide is again treated with an amino protected amino acid. This cycle is repeated several times and resin is removed by using trifluoroacetic acid.

Expert Solution & Answer

Want to see the full answer?

Check out a sample textbook solution

See solution

Answer 3

Question

Chapter 27, Problem 27.19P

Interpretation Introduction

(a)

Interpretation:

The structure of each compound involved in the given solid peptide phase synthesis is to be stated.

Concept introduction:

Solid phase peptide synthesis is a process in which an amino protected amino acid is treated with insoluble resin. After that, the amino acid is deprotected which gives rise to the formation of a dipeptide. This dipeptide is again treated with the amino protected amino acid. This cycle is repeated several times and resin is removed by using trifluoroacetic acid.

Interpretation Introduction

(b)

Interpretation:

A reason as to why Boc group is used on the side chain of the Lys group in the B→C step of the reaction is to be stated.

Concept introduction:

Solid peptide phase synthesis is a process in which an amino protected amino acid is treated with insoluble resin. After that, the amino acid is deprotected which give rise to the formation of a dipeptide. This dipeptide is again treated with an amino protected amino acid. This cycle is repeated several times and resin is removed by using trifluoroacetic acid.

Interpretation Introduction

(c)

Interpretation:

An explanation as to why Boc-Val is used rather than Fmoc-Val in the D→E step of the reaction is to be stated.

Concept introduction:

Solid peptide phase synthesis is a process in which an amino protected amino acid is treated with insoluble resin. After that, the amino acid is deprotected which give rise to the formation of a dipeptide. This dipeptide is again treated with an amino protected amino acid. This cycle is repeated several times and resin is removed by using trifluoroacetic acid.

Expert Solution & Answer

Want to see the full answer?

Check out a sample textbook solution

See solution

Answer 4

Question

Chapter 27, Problem 27.19P

Interpretation Introduction

(a)

Interpretation:

The structure of each compound involved in the given solid peptide phase synthesis is to be stated.

Concept introduction:

Solid phase peptide synthesis is a process in which an amino protected amino acid is treated with insoluble resin. After that, the amino acid is deprotected which gives rise to the formation of a dipeptide. This dipeptide is again treated with the amino protected amino acid. This cycle is repeated several times and resin is removed by using trifluoroacetic acid.

Interpretation Introduction

(b)

Interpretation:

A reason as to why Boc group is used on the side chain of the Lys group in the B→C step of the reaction is to be stated.

Concept introduction:

Solid peptide phase synthesis is a process in which an amino protected amino acid is treated with insoluble resin. After that, the amino acid is deprotected which give rise to the formation of a dipeptide. This dipeptide is again treated with an amino protected amino acid. This cycle is repeated several times and resin is removed by using trifluoroacetic acid.

Interpretation Introduction

(c)

Interpretation:

An explanation as to why Boc-Val is used rather than Fmoc-Val in the D→E step of the reaction is to be stated.

Concept introduction:

Solid peptide phase synthesis is a process in which an amino protected amino acid is treated with insoluble resin. After that, the amino acid is deprotected which give rise to the formation of a dipeptide. This dipeptide is again treated with an amino protected amino acid. This cycle is repeated several times and resin is removed by using trifluoroacetic acid.

Expert Solution & Answer

Want to see the full answer?

Check out a sample textbook solution

See solution

Answer 5

Chapter 27, Problem 27.19P

Interpretation Introduction

(a)

Interpretation:

The structure of each compound involved in the given solid peptide phase synthesis is to be stated.

Concept introduction:

Solid phase peptide synthesis is a process in which an amino protected amino acid is treated with insoluble resin. After that, the amino acid is deprotected which gives rise to the formation of a dipeptide. This dipeptide is again treated with the amino protected amino acid. This cycle is repeated several times and resin is removed by using trifluoroacetic acid.

Interpretation Introduction

(b)

Interpretation:

A reason as to why Boc group is used on the side chain of the Lys group in the B→C step of the reaction is to be stated.

Concept introduction:

Solid peptide phase synthesis is a process in which an amino protected amino acid is treated with insoluble resin. After that, the amino acid is deprotected which give rise to the formation of a dipeptide. This dipeptide is again treated with an amino protected amino acid. This cycle is repeated several times and resin is removed by using trifluoroacetic acid.

Interpretation Introduction

(c)

Interpretation:

An explanation as to why Boc-Val is used rather than Fmoc-Val in the D→E step of the reaction is to be stated.

Concept introduction:

Solid peptide phase synthesis is a process in which an amino protected amino acid is treated with insoluble resin. After that, the amino acid is deprotected which give rise to the formation of a dipeptide. This dipeptide is again treated with an amino protected amino acid. This cycle is repeated several times and resin is removed by using trifluoroacetic acid.

Answer 6

Chapter 27, Problem 27.19P

Interpretation Introduction

(a)

Interpretation:

The structure of each compound involved in the given solid peptide phase synthesis is to be stated.

Concept introduction:

Solid phase peptide synthesis is a process in which an amino protected amino acid is treated with insoluble resin. After that, the amino acid is deprotected which gives rise to the formation of a dipeptide. This dipeptide is again treated with the amino protected amino acid. This cycle is repeated several times and resin is removed by using trifluoroacetic acid.

Answer 7

Chapter 27, Problem 27.19P

Interpretation Introduction

(a)

Interpretation:

The structure of each compound involved in the given solid peptide phase synthesis is to be stated.

Concept introduction:

Solid phase peptide synthesis is a process in which an amino protected amino acid is treated with insoluble resin. After that, the amino acid is deprotected which gives rise to the formation of a dipeptide. This dipeptide is again treated with the amino protected amino acid. This cycle is repeated several times and resin is removed by using trifluoroacetic acid.

Answer 8

Interpretation Introduction

(b)

Interpretation:

A reason as to why Boc group is used on the side chain of the Lys group in the B→C step of the reaction is to be stated.

Concept introduction:

Solid peptide phase synthesis is a process in which an amino protected amino acid is treated with insoluble resin. After that, the amino acid is deprotected which give rise to the formation of a dipeptide. This dipeptide is again treated with an amino protected amino acid. This cycle is repeated several times and resin is removed by using trifluoroacetic acid.

Answer 9

Interpretation Introduction

(b)

Interpretation:

A reason as to why Boc group is used on the side chain of the Lys group in the B→C step of the reaction is to be stated.

Concept introduction:

Solid peptide phase synthesis is a process in which an amino protected amino acid is treated with insoluble resin. After that, the amino acid is deprotected which give rise to the formation of a dipeptide. This dipeptide is again treated with an amino protected amino acid. This cycle is repeated several times and resin is removed by using trifluoroacetic acid.

Answer 10

Interpretation Introduction

(c)

Interpretation:

An explanation as to why Boc-Val is used rather than Fmoc-Val in the D→E step of the reaction is to be stated.

Concept introduction:

Solid peptide phase synthesis is a process in which an amino protected amino acid is treated with insoluble resin. After that, the amino acid is deprotected which give rise to the formation of a dipeptide. This dipeptide is again treated with an amino protected amino acid. This cycle is repeated several times and resin is removed by using trifluoroacetic acid.

Answer 11

Interpretation Introduction

(c)

Interpretation:

An explanation as to why Boc-Val is used rather than Fmoc-Val in the D→E step of the reaction is to be stated.

Concept introduction:

Solid peptide phase synthesis is a process in which an amino protected amino acid is treated with insoluble resin. After that, the amino acid is deprotected which give rise to the formation of a dipeptide. This dipeptide is again treated with an amino protected amino acid. This cycle is repeated several times and resin is removed by using trifluoroacetic acid.

Answer 12

Expert Solution & Answer

Answer 13

Expert Solution & Answer

Answer 14

Want to see the full answer?

Check out a sample textbook solution

See solution

Answer 15

Ch. 27 - Prob. 27.1P Ch. 27 - Prob. 27.2P Ch. 27 - Prob. 27.3P Ch. 27 - Prob. 27.4P Ch. 27 - Prob. 27.5P Ch. 27 - Prob. 27.6P Ch. 27 - Prob. 27.8P Ch. 27 - Prob. 27.9P Ch. 27 - Prob. 27.10P Ch. 27 - Prob. 27.11P

Solution Summary: The author explains the structure of each compound involved in solid phase peptide synthesis.

Concept explainers

Videos

Want to see the full answer?

Chapter 27 Solutions