Biochemistry
6th Edition
ISBN: 9781305577206
Author: Reginald H. Garrett, Charles M. Grisham
Publisher: Cengage Learning
expand_more
expand_more
format_list_bulleted
Concept explainers
Question
Chapter 27, Problem 11P
Interpretation Introduction
Interpretation:
The enzyme suitable for such drugs as potential targets should be identified.
Concept introduction:
A catalyst substance may be a molecule that binds to associate protein and reduces its activity. Since obstruction an enzyme's activity will kill an infectious agent or correct a
Expert Solution & Answer
Want to see the full answer?
Check out a sample textbook solutionStudents have asked these similar questions
Long explanations are not needed. Direct answers would suffice.
a. Ribose-5-phosphate is produced by oxidative decarboxylation of 6-phosphogluconate catalyzed by the enzyme glucose-6-phosphate dehydrogenase.
I. True
II. False
b. The pentose phosphate pathway occurs in the mitochondrion of tissues actively engaged in synthesis of fatty
acids.
I. True
II. False
Help filling in the blanks:
The malate aspartate shuttle plays many roles in carbohydrate and amino acid metabolism. Malate can be transferred into the cytosol and interconverted in one enzymatic step to produce [oxaloacetate/glucose/PEP/pyruvate] for use in the pathway of [glycolysis/gluconeogenesis]. A product of the urea cycle, derived from aspartate, can also be converted to malate in one enzymatic step and shuttled into the mitochondria so that the urea cycle product can be used in [fatty acid synthesis/the citric acid cycle/β-oxidation]. The amino group from aspartate can be transferred to [oxalacetate/malate/fumarate/pyruvate/a- ketoglutarate] to form glutamate, which is then transported into the mitochondria. In fact many amino acids are transaminated in this way to form glutamate in the cytosol. In this way, incoming amino acids from the bloodstream can be shuttled into the liver mitochondria as glutamate for conversion by glutamate dehydrogenase to [glutamate/a-ketoglutarate…
Fill in the blanks. Acetaminophen toxicity can occur at high doses in the liver. because ___________ (what type of molecules?) can become saturated and other routes of metabolism take over.Please explain to me what the correct molecule(?) is and why it is correct. I understand that the glucuronidation and sulfation conjugation pathways become saturated, but am not understanding what molecule(s) it is/are that is/are becoming saturated leading to the other routes of metabolism and acetaminophen toxicity.
Knowledge Booster
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biochemistry and related others by exploring similar questions and additional content below.Similar questions
- Long explanations are not needed. Direct answers would suffice. a. High concentration of glucose 6-phosphate is inhibitory to the enzyme hexokinase. I. True II. False b. Which compound is formed when NAH reduces pyruvate (anaerobic condition)? I. lactate II. alpha-ketoglutarate III. glucose IV. oxaloacetatearrow_forwardHi, can someone help please. Thank you!arrow_forwarda- During intense exercise the transformation glucose to lactate causes very less ATP production compared to aerobic glycolysis. Explain, does anaerobic glycolysis lead to waste of energy in muscle? b-Glycogen phosphorylase enzyme catalyzes the removal of glucose from glycogen. Describe, glycogen metabolism regulation through glycogen phosphorylase.arrow_forward
- please help me in answering all even without explanation, thank you so much... please pleasearrow_forward1. State if true or false a. Gluconeogenesis is the exact opposite of the glycolytic pathway b. The end-product of glycolysis is Acetyl CoA c. There is no enzyme being secreted in the stomach for carbohydrate digestion d.Glycerol 3-phosphate shuttle, which is active in skeletal muscles and in the brain, bypasses Complex I and II of ETC resulting to less energy produced compared to malate-aspartate shuttle. e. Insoluble NSP has high water holding capacity and will increase the intestinal transit time of digesta.arrow_forwardLong explanations are not needed. Direct answers would suffice. a. In the TCA cycle, succinate dehydrogenase channels electrons directly into the electron transfer chain. I. True II. False b. Glucagon is a hormone that activates glycogenolysis. I. True II. Falsearrow_forward
- In 3-4 sentences, briefly explain how lactate is formed, the biological effect of lactate, and explain the biochemical process and path for conversion of lactate. 3. The hormones glucagon, epinephrine, and insulin, can regulate blood glucose levels to protect the brain. For each one provide a short explanation as to whether it raises or lowers glucose how it does this, and indicate whether it is metabolic or catabolic.arrow_forwardplease help me in answering all even without explanation, thank you so much... please pleasearrow_forwardPurpose: The purpose of this assignment is to explain how energy is extracted from foods and used to produce ATP and also describe how the body synthesizes new molecules.arrow_forward
- Long explanations are not needed. Direct answers would suffice. ***kind of in hurry so having the answer asap would greatly be appreciated, thank you :)) a. The first step in the pay-off phase of glycolysis is the oxidation of glyceraldehyde-3-phosphate to 1,3-bisphosphoglycerate. i. True ii. False b. Phosphofructokinase-1, the major flux-controlling enzyme of glycolysis is inhibited by _______. i. AMP ii. ATP iii. ADP iv. phosphoenol pyruvatearrow_forwardNeed in briefly explain.arrow_forwardplease helparrow_forward
arrow_back_ios
SEE MORE QUESTIONS
arrow_forward_ios
Recommended textbooks for you
- BiochemistryBiochemistryISBN:9781305577206Author:Reginald H. Garrett, Charles M. GrishamPublisher:Cengage Learning
Biochemistry
Biochemistry
ISBN:9781305577206
Author:Reginald H. Garrett, Charles M. Grisham
Publisher:Cengage Learning
Anaerobic Respiration; Author: Bozeman Science;https://www.youtube.com/watch?v=cDC29iBxb3w;License: Standard YouTube License, CC-BY