The reason for the T172D mutation of the AMPK to be locked in a permanently active state should be explained. Concept introduction: T172D shows that the mutation happens at position 172 in AMPK substitution from an essential amino acid to an aspartic resulting in charged aminoalkanoic acid (aspartic acid) in place of a polar neutral among acid (threonine).

Biochemistry

6th Edition

ISBN: 9781305577206

Author: Reginald H. Garrett, Charles M. Grisham

Publisher: Cengage Learning

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Question

Chapter 27, Problem 16P

Interpretation Introduction

Interpretation:

The reason for the T172D mutation of the AMPK to be locked in a permanently active state should be explained.

Concept introduction:

T172D shows that the mutation happens at position 172 in AMPK substitution from an essential amino acid to an aspartic resulting in charged aminoalkanoic acid (aspartic acid) in place of a polar neutral among acid (threonine).

Expert Solution & Answer

Solution Summary: The author explains the reason for the T172D mutation of the AMPK to be locked in a permanently active state.

Concept explainers

Chapter 27 Solutions