Biochemistry
6th Edition
ISBN: 9781305577206
Author: Reginald H. Garrett, Charles M. Grisham
Publisher: Cengage Learning
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Chapter 27, Problem 18P
Interpretation Introduction
(a)
Interpretation:
About Leptin’s mechanism of action.
Concept Introduction:
Mechanisms of Leptin action and Leptin resistance. The fatty tissue-derived secretion Leptin acts via its receptor (LRb) within the brain to manage energy balance and system perform. LRb signal via STAT3 and variety of different pathways is needed for the totality of Leptin action.
Interpretation Introduction
(b)
Interpretation:
About loss of function in a protein.
Concept Introduction:
Leptin binds to its receptors (Leptin receptors) having a specific membrane-spanning protein expressed within the central nervous system. Once Leptin binds to its receptors, it starts a complex and tough signal transduction pathway linking to the hormone transduction pathway.
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