(a) Interpretation: The isotopic labeling distribution in the synthesis of cholesterol from mevalonate labeled with 14 C in its carboxyl carbon atom should be determined. Concept introduction: The steroid can be defined as a biologically active organic compound that has four rings organized in a definite molecular configuration. The steroid core structure consists of seventeen carbon atoms. These carbon atoms are bonded in four rings. Steroids generally show variation due to the presence of functional groups attached to the core ring and by its oxidation state. Cholesterol is a type of steroid.

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Answer 1

Question

Chapter 26, Problem 18P

Interpretation Introduction

(a)

Interpretation:

The isotopic labeling distribution in the synthesis of cholesterol from mevalonate labeled with ¹⁴C in its carboxyl carbon atom should be determined.

Concept introduction:

The steroid can be defined as a biologically active organic compound that has four rings organized in a definite molecular configuration. The steroid core structure consists of seventeen carbon atoms. These carbon atoms are bonded in four rings. Steroids generally show variation due to the presence of functional groups attached to the core ring and by its oxidation state. Cholesterol is a type of steroid.

Interpretation Introduction

(b)

Interpretation:

The isotopic labeling distribution in the synthesis of cholesterol from malonyl CoA labeled with ¹⁴Cin its carboxyl carbon atom should be determined.

Concept introduction:

The steroid can be defined as a biologically active organic compound that has four rings organized in a definite molecular configuration. The steroid core structure consists of seventeen carbon atoms. These carbon atoms are bonded in four rings. Steroids generally show variation due to the presence of functional groups attached to the core ring and by its oxidation state. Cholesterol is a type of steroid.

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The beta-lactamase hydrolyzes the lactam-ring in penicillin. Describe the mechanism of hydrolysis, insuring to include the involvement of S, D, & K in the reaction sequence. Please help

To map the active site of beta-lactamase, the enzyme was hydrolyzed with trypsin to yield a hexapeptide (P1) with the following amino acids. Glu, Lys, Leu, Phe, Met, and Ser. Treatment of P1 with phenyl isothiocyanate yielded a PTH derivative of phenylalanine and a peptide (P2). Treatment of P1 with cyanogenbromide gave an acidic tetrapeptide (P3) and a dipeptide (P4).Treatment of P2 with 1-fluoro-2,4-dinitrobenzene, followed by complete hydrolysis, yields N-2,4-dinitrophenyl-Glu. P1, P2, and P3 contain the active site serine. Why doesn't D in this hexapeptide not participate in the hydrolysis of the beta-lactam ring even though S, K, and D are involved in the catalyst?

To map the active site of -lactamase, the enzyme was hydrolyzed with trypsin to yield a hexapeptide (P1) with the following amino acids. Glu, Lys, Leu, Phe, Met, and Ser. Treatment of P1 with phenyl isothiocyanate yielded a PTH derivative of phenylalanine and a peptide (P2). Treatment of P1 with cyanogenbromide gave an acidic tetrapeptide (P3) and a dipeptide (P4).Treatment of P2 with 1-fluoro-2,4-dinitrobenzene, followed by complete hydrolysis, yields N-2,4-dinitrophenyl-Glu. P1, P2, and P3 contain the active site serine. Using the experimental results described above derive the primary sequence of the active site hexapeptide. Please help!

Answer 2

Question

Chapter 26, Problem 18P

Interpretation Introduction

(a)

Interpretation:

The isotopic labeling distribution in the synthesis of cholesterol from mevalonate labeled with ¹⁴C in its carboxyl carbon atom should be determined.

Concept introduction:

The steroid can be defined as a biologically active organic compound that has four rings organized in a definite molecular configuration. The steroid core structure consists of seventeen carbon atoms. These carbon atoms are bonded in four rings. Steroids generally show variation due to the presence of functional groups attached to the core ring and by its oxidation state. Cholesterol is a type of steroid.

Interpretation Introduction

(b)

Interpretation:

The isotopic labeling distribution in the synthesis of cholesterol from malonyl CoA labeled with ¹⁴Cin its carboxyl carbon atom should be determined.

Concept introduction:

The steroid can be defined as a biologically active organic compound that has four rings organized in a definite molecular configuration. The steroid core structure consists of seventeen carbon atoms. These carbon atoms are bonded in four rings. Steroids generally show variation due to the presence of functional groups attached to the core ring and by its oxidation state. Cholesterol is a type of steroid.

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Answer 3

Question

Chapter 26, Problem 18P

Interpretation Introduction

(a)

Interpretation:

The isotopic labeling distribution in the synthesis of cholesterol from mevalonate labeled with ¹⁴C in its carboxyl carbon atom should be determined.

Concept introduction:

The steroid can be defined as a biologically active organic compound that has four rings organized in a definite molecular configuration. The steroid core structure consists of seventeen carbon atoms. These carbon atoms are bonded in four rings. Steroids generally show variation due to the presence of functional groups attached to the core ring and by its oxidation state. Cholesterol is a type of steroid.

Interpretation Introduction

(b)

Interpretation:

The isotopic labeling distribution in the synthesis of cholesterol from malonyl CoA labeled with ¹⁴Cin its carboxyl carbon atom should be determined.

Concept introduction:

The steroid can be defined as a biologically active organic compound that has four rings organized in a definite molecular configuration. The steroid core structure consists of seventeen carbon atoms. These carbon atoms are bonded in four rings. Steroids generally show variation due to the presence of functional groups attached to the core ring and by its oxidation state. Cholesterol is a type of steroid.

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Answer 4

Question

Chapter 26, Problem 18P

Interpretation Introduction

(a)

Interpretation:

The isotopic labeling distribution in the synthesis of cholesterol from mevalonate labeled with ¹⁴C in its carboxyl carbon atom should be determined.

Concept introduction:

The steroid can be defined as a biologically active organic compound that has four rings organized in a definite molecular configuration. The steroid core structure consists of seventeen carbon atoms. These carbon atoms are bonded in four rings. Steroids generally show variation due to the presence of functional groups attached to the core ring and by its oxidation state. Cholesterol is a type of steroid.

Interpretation Introduction

(b)

Interpretation:

The isotopic labeling distribution in the synthesis of cholesterol from malonyl CoA labeled with ¹⁴Cin its carboxyl carbon atom should be determined.

Concept introduction:

The steroid can be defined as a biologically active organic compound that has four rings organized in a definite molecular configuration. The steroid core structure consists of seventeen carbon atoms. These carbon atoms are bonded in four rings. Steroids generally show variation due to the presence of functional groups attached to the core ring and by its oxidation state. Cholesterol is a type of steroid.

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Answer 5

Chapter 26, Problem 18P

Interpretation Introduction

(a)

Interpretation:

The isotopic labeling distribution in the synthesis of cholesterol from mevalonate labeled with ¹⁴C in its carboxyl carbon atom should be determined.

Concept introduction:

The steroid can be defined as a biologically active organic compound that has four rings organized in a definite molecular configuration. The steroid core structure consists of seventeen carbon atoms. These carbon atoms are bonded in four rings. Steroids generally show variation due to the presence of functional groups attached to the core ring and by its oxidation state. Cholesterol is a type of steroid.

Interpretation Introduction

(b)

Interpretation:

The isotopic labeling distribution in the synthesis of cholesterol from malonyl CoA labeled with ¹⁴Cin its carboxyl carbon atom should be determined.

Concept introduction:

The steroid can be defined as a biologically active organic compound that has four rings organized in a definite molecular configuration. The steroid core structure consists of seventeen carbon atoms. These carbon atoms are bonded in four rings. Steroids generally show variation due to the presence of functional groups attached to the core ring and by its oxidation state. Cholesterol is a type of steroid.

Answer 6

Chapter 26, Problem 18P

Interpretation Introduction

(a)

Interpretation:

The isotopic labeling distribution in the synthesis of cholesterol from mevalonate labeled with ¹⁴C in its carboxyl carbon atom should be determined.

Concept introduction:

The steroid can be defined as a biologically active organic compound that has four rings organized in a definite molecular configuration. The steroid core structure consists of seventeen carbon atoms. These carbon atoms are bonded in four rings. Steroids generally show variation due to the presence of functional groups attached to the core ring and by its oxidation state. Cholesterol is a type of steroid.

Answer 7

Chapter 26, Problem 18P

Interpretation Introduction

(a)

Interpretation:

The isotopic labeling distribution in the synthesis of cholesterol from mevalonate labeled with ¹⁴C in its carboxyl carbon atom should be determined.

Concept introduction:

The steroid can be defined as a biologically active organic compound that has four rings organized in a definite molecular configuration. The steroid core structure consists of seventeen carbon atoms. These carbon atoms are bonded in four rings. Steroids generally show variation due to the presence of functional groups attached to the core ring and by its oxidation state. Cholesterol is a type of steroid.

Answer 8

Interpretation Introduction

(b)

Interpretation:

The isotopic labeling distribution in the synthesis of cholesterol from malonyl CoA labeled with ¹⁴Cin its carboxyl carbon atom should be determined.

Concept introduction:

The steroid can be defined as a biologically active organic compound that has four rings organized in a definite molecular configuration. The steroid core structure consists of seventeen carbon atoms. These carbon atoms are bonded in four rings. Steroids generally show variation due to the presence of functional groups attached to the core ring and by its oxidation state. Cholesterol is a type of steroid.

Answer 9

Interpretation Introduction

(b)

Interpretation:

The isotopic labeling distribution in the synthesis of cholesterol from malonyl CoA labeled with ¹⁴Cin its carboxyl carbon atom should be determined.

Concept introduction:

The steroid can be defined as a biologically active organic compound that has four rings organized in a definite molecular configuration. The steroid core structure consists of seventeen carbon atoms. These carbon atoms are bonded in four rings. Steroids generally show variation due to the presence of functional groups attached to the core ring and by its oxidation state. Cholesterol is a type of steroid.

Answer 10

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Answer 11

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Answer 12

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Answer 13

Ch. 26 - Prob. 1P Ch. 26 - Prob. 2P Ch. 26 - Prob. 3P Ch. 26 - Prob. 4P Ch. 26 - Prob. 5P Ch. 26 - Prob. 6P Ch. 26 - Prob. 7P Ch. 26 - Prob. 8P Ch. 26 - Prob. 9P Ch. 26 - Prob. 10P

Solution Summary: The author explains the isotopic labeling distribution in the synthesis of cholesterol from mevalonate labeled with 14 C in its carboxyl carbon atom.

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