The opinion for the given statement “Cholesterol plays an essential role in the body, making cells, hormones and tissues” should be determined. Concept introduction: When the levels of cholesterol rise abruptly then it is a condition known as hypercholesterolemia. When this disease is genetic then it is known as familial hypercholesterolemia. In this disease, the concentration of cholesterol is very high even in young children. Causes of familial hypercholesterolemia are a mutation that results in this disease. Also, the malfunctioning of the Low-Density Lipoprotein (LDL) receptor results in this disease.

Question

The beta-lactamase hydrolyzes the lactam-ring in penicillin. Describe the mechanism of hydrolysis, insuring to include the involvement of S, D, & K in the reaction sequence. Please help

Answer 1

Question

Chapter 26, Problem 21P

Interpretation Introduction

Interpretation:

The opinion for the given statement “Cholesterol plays an essential role in the body, making cells, hormones and tissues” should be determined.

Concept introduction:

When the levels of cholesterol rise abruptly then it is a condition known as hypercholesterolemia. When this disease is genetic then it is known as familial hypercholesterolemia. In this disease, the concentration of cholesterol is very high even in young children. Causes of familial hypercholesterolemia are a mutation that results in this disease. Also, the malfunctioning of the Low-Density Lipoprotein (LDL) receptor results in this disease.

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The beta-lactamase hydrolyzes the lactam-ring in penicillin. Describe the mechanism of hydrolysis, insuring to include the involvement of S, D, & K in the reaction sequence. Please help

To map the active site of beta-lactamase, the enzyme was hydrolyzed with trypsin to yield a hexapeptide (P1) with the following amino acids. Glu, Lys, Leu, Phe, Met, and Ser. Treatment of P1 with phenyl isothiocyanate yielded a PTH derivative of phenylalanine and a peptide (P2). Treatment of P1 with cyanogenbromide gave an acidic tetrapeptide (P3) and a dipeptide (P4).Treatment of P2 with 1-fluoro-2,4-dinitrobenzene, followed by complete hydrolysis, yields N-2,4-dinitrophenyl-Glu. P1, P2, and P3 contain the active site serine. Why doesn't D in this hexapeptide not participate in the hydrolysis of the beta-lactam ring even though S, K, and D are involved in the catalyst?

To map the active site of -lactamase, the enzyme was hydrolyzed with trypsin to yield a hexapeptide (P1) with the following amino acids. Glu, Lys, Leu, Phe, Met, and Ser. Treatment of P1 with phenyl isothiocyanate yielded a PTH derivative of phenylalanine and a peptide (P2). Treatment of P1 with cyanogenbromide gave an acidic tetrapeptide (P3) and a dipeptide (P4).Treatment of P2 with 1-fluoro-2,4-dinitrobenzene, followed by complete hydrolysis, yields N-2,4-dinitrophenyl-Glu. P1, P2, and P3 contain the active site serine. Using the experimental results described above derive the primary sequence of the active site hexapeptide. Please help!