Concept explainers
(a)
Interpretation:
Whether or not HMG-CoA produced from acetyl CoA (1) can be produced in a one-step process, (2) can be produced in a multistep process, or (3) cannot be produced from acetyl CoA has to be indicated.
Concept introduction:
Fatty acids are molecules that are long hydrocarbon chain of
The fatty acids are broken down to provide energy. The breakdown of fatty acids is a three parts process. In the first part, the fatty acid is activated. In the second part, the transportation of fatty acid into the mitochondrial matrix is facilitated by a shuttle mechanism. In the third part, the fatty acid is readily oxidized, cycling through a series of four reactions. In these series of reactions, acyl CoA is degraded to acetyl CoA. This pathway is termed a β-oxidation pathway. Acetyl CoA, FADH2, and NADH are produced in this reaction.
Ketogenesis is a
cleavage and hydrogenation to produce ketone bodies.
(b)
Interpretation:
Whether or not acetyl ACP produced from acetyl CoA (1) can be produced in a one-step process, (2) can be produced in a multistep process, or (3) cannot be produced from acetyl CoA has to be indicated.
Concept introduction:
Fatty acids are molecules that are long hydrocarbon chain of carboxylic acid. They are building blocks of fat in humans and animals.
The fatty acids are broken down to provide energy. The breakdown of fatty acids is a three parts process. In the first part, the fatty acid is activated. In the second part, the transportation of fatty acid into the mitochondrial matrix is facilitated by a shuttle mechanism. In the third part, the fatty acid is readily oxidized, cycling through a series of four reactions. In these series of reactions, acyl CoA is degraded to acetyl CoA. This pathway is termed a β-oxidation pathway. Acetyl CoA, FADH2, and NADH are produced in this reaction.
Lipogenesis is the process employed for the synthesis of fatty acid. The starting precursor for the synthesis is
A cyclic process occurs in the enzyme fatty acid synthase. One turn of this cyclic process constitutes four reactions. The various intermediates formed in the process are associated with a carrier protein known as ACP.
(c)
Interpretation:
Whether or not mevalonate produced from acetyl CoA (1) can be produced in a one-step process, (2) can be produced in a multistep process, or (3) cannot be produced from acetyl CoA has to be indicated.
Concept introduction:
Fatty acids are molecules that are long hydrocarbon chain of carboxylic acid. They are building blocks of fat in humans and animals.
The fatty acids are broken down to provide energy. The breakdown of fatty acids is a three parts process. In the first part, the fatty acid is activated. In the second part, the transportation of fatty acid into the mitochondrial matrix is facilitated by a shuttle mechanism. In the third part, the fatty acid is readily oxidized, cycling through a series of four reactions. In these series of reactions, acyl CoA is degraded to acetyl CoA. This pathway is termed a β-oxidation pathway. Acetyl CoA, FADH2, and NADH are produced in this reaction.
(d)
Interpretation:
Whether or not acetoacetate produced from acetyl CoA (1) can be produced in a one-step process, (2) can be produced in a multistep process, or (3) cannot be produced from acetyl CoA has to be indicated.
Concept introduction:
Fatty acids are molecules that are long hydrocarbon chain of carboxylic acid. They are building blocks of fat in humans and animals.
The fatty acids are broken down to provide energy. The breakdown of fatty acids is a three parts process. In the first part, the fatty acid is activated. In the second part, the transportation of fatty acid into the mitochondrial matrix is facilitated by a shuttle mechanism. In the third part, the fatty acid is readily oxidized, cycling through a series of four reactions. In these series of reactions, acyl CoA is degraded to acetyl CoA. This pathway is termed a β-oxidation pathway. Acetyl CoA, FADH2, and NADH are produced in this reaction.
Ketogenesis is a metabolic process by which ketone bodies are produced by the breakdown of fatty acids and ketogenic amino acids. This metabolic process supplies organs with needed energy under certain circumstances such as starvation. Fatty acid molecules degrade into acetyl CoA which are utilized as reactants in the process of ketogenesis. Acetyl CoA undergoes the process of condensation twice, followed by chain
cleavage and hydrogenation to produce ketone bodies.

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Chapter 25 Solutions
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