GENETIC ANALYSIS: AN INTEG. APP. W/MAS
2nd Edition
ISBN: 9781323142790
Author: Sanders
Publisher: Pearson Custom Publishing
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Chapter 22, Problem 23P
Cystic fibrosis (CF) is the most common autosomal recessive disorder in certain Caucasian populations. In some populations, approximately
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Sickle cell anemia is a genetically inherited autosomal recessive trait in which results in a condition that there are not enough healthy red blood cells to carry oxygen throughout the body due to the production of red blood cells that are sickle shaped. The frequency of the sickle cell condition is as high as 10% in Central Africa compared to 0.5% in the United States.
Calculate the frequency of the normal and carries of the sickle cell condition.
Tony has a sister with cystic fibrosis (CF). Neither of his parents have CF, nor does Tony. Tony is expecting a child with Tina. Tina
does not have CF, but otherwise her family history is unknown.
A) What is the probability that Tony is heterozygous for the CF gene?
B) If the frequency of heterozygotes in the general population is 1/50, what is the probability that Tony and Tina's child will have
CF?
Two parents, without any family history of cystic fibrosis (CF), have a child with CF.
A. What do you predict the genotypes of the parents to be? (CF is a recessive disorder.)
B. What is the chance that the next child of these two parents will also have CF?
Chapter 22 Solutions
GENETIC ANALYSIS: AN INTEG. APP. W/MAS
Ch. 22 - 20.1 Compare and contrast the terms in each of the...Ch. 22 - In a population, what is the consequence of...Ch. 22 - 20.3 Identify and describe the evolutionary forces...Ch. 22 - Describe how natural selection can produce...Ch. 22 - Thinking creatively about evolutionary mechanisms,...Ch. 22 - 20.6 Genetic drift, an evolutionary process...Ch. 22 - Over the course of many generations in a small...Ch. 22 - Catastrophic events such as loss of habitat,...Ch. 22 - 20.9 George Udny Yule was wrong in suggesting that...Ch. 22 - 20.10 The ability to taste the bitter compound...
Ch. 22 - Figure 20.6 illustrates the effect of an ethanol ...Ch. 22 - 20.12 Biologists have proposed that the use of...Ch. 22 - 20.13 Two populations of deer, one of them large...Ch. 22 - 20.14 Directional selection presents an apparent...Ch. 22 - 20.15 What is inbreeding depression? Why is...Ch. 22 - 20.16 Certain animal species, such as the...Ch. 22 - Genetic Analysis 20.1 predicts the number of...Ch. 22 - 20.18 In a population of rabbits, and . The...Ch. 22 - Sickle cell disease (SCD) is found in numerous...Ch. 22 - 20.20 Epidemiologic data on the population in the...Ch. 22 - The frequency of tasters and nontasters of PTC...Ch. 22 - Tay-Sachs disease is an autosomal recessive...Ch. 22 - 20.23 Cystic fibrosis (CF) is the most common...Ch. 22 - 20.24 In the mouse, Mus musculus, survival in...Ch. 22 - 20.25 In a population of flowers growing in a...Ch. 22 - Assume that the flower population described in the...Ch. 22 - 20.27 ABO blood type is examined in a Taiwanese...Ch. 22 - 20.28 A total ofmembers of a Central American...Ch. 22 - 20.29 A sample offield mice contains individuals...Ch. 22 - Prob. 30PCh. 22 - Albinism, an autosomal recessive trait...Ch. 22 - Prob. 32PCh. 22 - 20.33 Evaluate the following pedigree, and answer...Ch. 22 - Evaluate the following pedigree, and answer the...Ch. 22 - The following is a partial pedigree of the British...Ch. 22 - Draw a separate hypothetical pedigree identifying...Ch. 22 - Prob. 37PCh. 22 - 20.38 Achromatopsia is a rare autosomal recessive...Ch. 22 - 20.39 New allopolyploid plant species can arise by...
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- Cystic Fibrosis (CF) is an autosomal recessive condition. Therefore, heterozygous (Cc) carriers do not display symptoms. Two parents who are carriers plan to start a family and you are a genetic counselor helping to advise them about their chances of having children affected by CF. a) Suppose the couple has 4 children, each one year apart. What is the probability that all 4 children will inherit CF? b) What is the probability that any 3 of their 4 children will not inherit CF, but 1 will be affected? c) What is the probability that their first child will not inherit CF, but the younger 3 children will inherit CF?arrow_forwardBACKGROUND: Sickle cell disease is caused by a change in the gene for hemoglobin, which is the oxygen-carrying protein in red blood cells. Individuals who are homozygous for the sickle cell trait often cannot endure exercise. Individuals who are heterozygous for the trait can have sickle cell attacks under extreme conditions. Normal individuals (genotype: Hbnorm Hbnorm ) have only normal hemoglobin. Homozygous sickle cell individuals (genotype: Hbsc Hbsc ) 'have only sickle cell hemoglobin. Heterozygous individuals (genotype: Hbnorm Hbsc ) have both normal and sickle cell hemoglobin. terry Smith collapsed while running a race for his track team. A doctor said he had a sickle cell attack. Genetic tests were run on several family members. The test results are shown below. An X indicates that form of hemoglobin in red blood cells. PROBLEM: How can you determine the genotypes of people in a family? Subject Normal Hemoglobin Sickle Cell Hemoglobin Jerry Jerry's brother Jerry's younger…arrow_forwardGive only typing answer with explanation and conclusion Travis and Marcy, a Caucasian couple, are pregnant with their first child. Travis has a prior child with cystic fibrosis (autosomal recessive). He has refused to pursue carrier testing but Marcy has had negative carrier testing. Note: Carrier testing can identify 90% of carriers of CF accurately and approximately 1/25 Caucasian's are carriers of CF. What is the chance they will have a child with CF? Group of answer choices 1/964 1/140 1/25 1/209arrow_forward
- Travis and Marcy, a Caucasian couple, are pregnant with their first child. Travis has a prior child with cystic fibrosis (autosomal recessive). He has refused to pursue carrier testing but Marcy has had negative carrier testing. Note: Carrier testing can identify 90% of carriers of CF accurately and approximately 1/25 Caucasian's are carriers of CF. What is the chance they will have a child with CF? 1/140 1/25 1/964 Need it ASAP pleasearrow_forwardSickle-cell disease is an autosomal recessive genetic disorder. How many mutated hemoglobin alleles do people with sickle-cell disease have?arrow_forwardA given autosomal locus has three possible alleles (A1, A2, and A3). Assuming that the numbers of individuals with the six possible genotypes are as follows, what would be the frequency of the A1 allele in the population? A1A1 = 30 A1A2 = 27 A2A2 = 12 A1A3 = 17 A2A3 = 10 A3A3 = 4 What would be the frequency of the A3A3 genotype? Assume the population is under Hardy-Weinberg equilibrium. A. 0.182 B. 0.27 C. 0.03 D. 0.317 E. 0.107 F. 0.09arrow_forward
- Cystic fibrosis in humans is caused by a recessive allele. A man is known to be a carrier of the cystic fibrosis allele. He marries a phenotypically normal woman. In the general population, the incidence of cystic fibrosis at birth is approximately 1 in 1,700. Assume Hardy-Weinberg proportions. What is the probability that the wife is also a carrier? Answer in decimal number only (three decimal places; example: 0.123). What is the probability that their first child will be affected? Answer in decimal number only (three decimal places; example: 0.123).arrow_forwardCystic fibrosis is an autosomal recessive disorder that affects 1 in 3 000 newborns with Caucasian background. It causes thick mucus build up in various organs and can cause damages and problems in respiratory and digestive systems. a) What is the frequency of the cystic fibrosis allele in the Caucasian population? Show all your work and express your answer as a value between 0 and 1 rounded to two decimal places. b) What percentage of the Caucasian population would be carriers for cystic fibrosis? Show all your work and express your answer rounded to two decimal places. c)If two individuals are carriers of the cystic fibrosis allele, what is the probability that they would have a girl without cystic fibrosis? Show all your work (including the Punnett square) and express your answer as a value between 0 and 1 rounded to two decimal places.arrow_forwardBelow in Figure 1 is a pedigree for a family afflicted by a genetic disorder. In some populations, Cystic fibrosis has an incidence of 1 in 2500 newborns. The carrier frequency calculated from this is 1/25. Analyze the pedigree below assuming the disease is similar to cystic fibrosis in incidence and carrier frequency. However this disease may not have the same type of genetic transmission as cystic fibrosis. What type of genetic transmission is most consistent with the pedigree? Label all the individuals that you can determine, with hypothesized genotypes. Label the individuals that have unknown genotypes with possible genotypes. Assuming her father is known to NOT be a carrier, calculate the probability that IV1 is a carrier for disease. Use the Χ2 test to determine whether your proposed transmission fits this data.arrow_forward
- Below in Figure 1 is a pedigree for a family afflicted by a genetic disorder. In some populations, Cystic fibrosis has an incidence of 1 in 2500 newborns. The carrier frequency calculated from this is 1/25. Analyze the pedigree below assuming the disease is similar to cystic fibrosis in incidence and carrier frequency. However this disease may not have the same type of genetic transmission as cystic fibrosis. What type of genetic transmission is most consistent with the pedigree? Label all the individuals that you can determine, with hypothesized genotypes. Label the individuals that have unknown genotypes with possible genotypes. Assuming her father is known to NOT be a carrier, calculate the probability that IV1 is a carrier for disease. Use the Χ2 test to determine whether your proposed transmission fits this data.arrow_forwardPlease solvearrow_forwardIn Sweden 1/500 are born with an autosomal recessive disorder called thalassemia. What is the carrier frequency within the population?arrow_forward
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