Chapter 19, Problem 25P

Interpretation Introduction

Interpretation:

The starting material required to synthesize the given compounds by acylation of enolate is to be provided.

Concept introduction:

The carbon–carbon bond forming reaction, useful for the synthesis of $\beta -$ keto ester, is known as Claisen condensation reaction.

In carbonyl condensation reaction, the enolate of one carbonyl compound reacts with the carbonyl group of another.

The Claisen condensation between esters containing α-hydrogens, promoted by a base such as sodium ethoxide, affords β-ketoesters.

The intramolecular version is known as Dieckmann Condensation.

Claisen condensation is a reversible reaction.