Biochemistry
6th Edition
ISBN: 9781305577206
Author: Reginald H. Garrett, Charles M. Grisham
Publisher: Cengage Learning
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Chapter 19, Problem 18P
Interpretation Introduction
Interpretation:
Remembering and understanding the TCA cycle along with its reaction.
Concept Introduction:
A series of enzyme catalyzed
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4- Salicylamides are inhibitors for an enzyme called scytalone dehydratase. SAR shows that
there are three important hydrogen bonding interactions. Explain whether you think
quinazolines could act as a bioisostere for salicylamides.
HBA
OH
O 00
N
NHR
Quinazolines
Salicylamides
Ph
HBA
5- Structure IX (X = NH) is an inhibitor of a metalloenzyme called thermolysin and forms
interactions as shown. Explain why the analogue (X = O) has reduced binding affinity by a
factor of 1000 and why the analogue (X = SH) has roughly the same binding affinity.
Structure IX
H
HBD
Ala-113
R
Chapter 19 Solutions
Biochemistry
Ch. 19 - Radiolabeling with 14C-Glutamate Describe the...Ch. 19 - Prob. 2PCh. 19 - Assessing the Effect of Active-Site...Ch. 19 - Understanding the Mechanism of the -Ketoglutarate...Ch. 19 - Understanding the Action of Fluoroacetate on the...Ch. 19 - Prob. 6PCh. 19 - Prob. 7PCh. 19 - Prob. 8PCh. 19 - Prob. 9PCh. 19 - Prob. 10P
Ch. 19 - Prob. 11PCh. 19 - Prob. 12PCh. 19 - Prob. 13PCh. 19 - Prob. 14PCh. 19 - Prob. 15PCh. 19 - Prob. 16PCh. 19 - Understanding the Oxidation of Glucose and Its...Ch. 19 - Prob. 18PCh. 19 - Prob. 19PCh. 19 - Prob. 20PCh. 19 - Complete oxidation of a 16-carbon fatty acid can...Ch. 19 - Study Figure 19.18 and decide which of the...Ch. 19 - Prob. 23P
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