Biochemistry
6th Edition
ISBN: 9781305577206
Author: Reginald H. Garrett, Charles M. Grisham
Publisher: Cengage Learning
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Chapter 19, Problem 3P
Assessing the Effect of Active-Site Phosphorylation on Enzyme Activity (Integrates with Chapter 15.) The serine residue of isocitrate dehydroenase that is phosphorylated by protein kinase lies within the active site of the enzyme. This situation contrasts with most other examples of coa1ent modification by protein phosphorylation. where the phosphorylation occurs at a sate remote from the active site. What direct effect do you think such active-site phosphorylation might have on the catalytic activity of isocitrate dehydrogcn.ise? (Sec Barford, D., 1991. Molecular mechanisms for the control of enzymic activity by protein phosphorytation. Biochimica et Biophysica Acta 1133:55—62.)
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12. When glutamic acid is heated to 180°C., it loses a molecule of water to form a
lactam. The bond that creates the lactam is an amide bond that forms between the
amino nitrogen and the carbon of the side chain -COOH group. What is the most
reasonable structure for this lactam? (NOTE: The structure of glutamic acid is shown
in Question 1.)
COOH
COOH
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C
D
COOH
B
COOH
E
COOH
10. Which one of the
following compounds is
the major organic product
of the series of reactions
shown here?
Ph
A
OH
Ph
B
CO₂Et
Br
-H
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CO₂Et
1. NaOEt
1. NaOH, H₂O
2. H3O+
2. PhCH2CH2Br
3. heat
NH2
Ph
OH
NH2
0
OH
Ph
OH
NH2
Ph
D
NH2
E
OH
1. What is the isoelectric point of glutamic acid?
(Glutamic acid has pKa1 2.10, pKa2 4.07, pKaз 9.47)
A) pH 2.1
D) pH 6.8
B) pH 3.1
C) pH 4.1
E) pH 9.5
HO
NH2
Glutamic acid
(shown without charges)
OH
Chapter 19 Solutions
Biochemistry
Ch. 19 - Radiolabeling with 14C-Glutamate Describe the...Ch. 19 - Prob. 2PCh. 19 - Assessing the Effect of Active-Site...Ch. 19 - Understanding the Mechanism of the -Ketoglutarate...Ch. 19 - Understanding the Action of Fluoroacetate on the...Ch. 19 - Prob. 6PCh. 19 - Prob. 7PCh. 19 - Prob. 8PCh. 19 - Prob. 9PCh. 19 - Prob. 10P
Ch. 19 - Prob. 11PCh. 19 - Prob. 12PCh. 19 - Prob. 13PCh. 19 - Prob. 14PCh. 19 - Prob. 15PCh. 19 - Prob. 16PCh. 19 - Understanding the Oxidation of Glucose and Its...Ch. 19 - Prob. 18PCh. 19 - Prob. 19PCh. 19 - Prob. 20PCh. 19 - Complete oxidation of a 16-carbon fatty acid can...Ch. 19 - Study Figure 19.18 and decide which of the...Ch. 19 - Prob. 23P
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