(a)
Interpretation:
The coenzyme transfers an acyl group from one substrate to another should be determined.
Concept introduction:
Cofactors that are organic molecule are called coenzymes;
Coenzymes are derived from Vitamins which are substance needed in small amounts for normal body function that the body cannot synthesize in adequate amounts.
Thiamine pyrophosphate (TPP) is the coenzyme required by enzymes that catalyse the transfer of an acyl group.
(b)
Interpretation:
The function of FAD on the pyruvate dehydrogenase complex should be determined.
Concept introduction:
Cofactors that are organic molecule are called coenzymes;
Coenzymes are derived from Vitamins which are substance needed in small amounts for normal body function that the body cannot synthesize in adequate amounts.
(c)
Interpretation:
The function of
Concept introduction:
Cofactors that are organic molecule are called coenzymes;
Coenzymes are derived from Vitamins which are substance needed in small amounts for normal body function that the body cannot synthesize in adequate amounts.
(d)
Interpretation:
The reaction necessary for proper blood clotting is catalysed by vitamin
Concept introduction:
Cofactors that are organic molecule are called coenzymes;
Coenzymes are derived from Vitamins which are substance needed in small amounts for normal body function that the body cannot synthesize in adequate amounts.
(e)
Interpretation:
The coenzyme are used for decarboxylation reaction should be determined.
Concept introduction:
Cofactors that are organic molecule are called coenzymes;
Coenzymes are derived from Vitamins which are substance needed in small amounts for normal body function that the body cannot synthesize in adequate amounts.
(f)
Interpretation:
The various kinds of substrates should be determined for the decarboxylation coenzyme work on.
Concept introduction:
Cofactors that are organic molecule are called coenzymes;
Coenzymes are derived from Vitamins which are substance needed in small amounts for normal body function that the body cannot synthesize in adequate amounts.
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Check out a sample textbook solutionChapter 18 Solutions
Essential Organic Chemistry, Global Edition
- Match the coenzymes and'or substrates with their corresponding glycolytic enzymes. Note that an enzyme can match with more than one coenzyme or substrate in the list v ATP A. Phosphofructokinase-1 NAD* B. ATPase v Dihydroxyacetone phosphate C Glyceraldehyde 3-phosphate dehydrogenase D. Glucose 1-dehydrogenase E Triose phosphate isomerasearrow_forward8.Which of the following enzymes are required for the shown reaction? HS-CoA ÇO CH, CH1 CooH NAD* NADH S-COA a. dihydrolipoyl transacetylase b. dihydrolipoyl dehydrogenase c. Both a and b d. Neither a nor barrow_forwardExplanation: b) The metabolic pathway of warfarin is deficient since this patient is a Warfarin is partially metabolised, most of it remaining in the bloodstream of warfarin's therapeutic effect. g 5. The addition of glucuronic acid to a drug: a. Decreases its water solubility b. Leads to inactivation of the drug C. c. Is an example of a Phase I metabolism reaction d. Occurs at the same rate in adults and new-borns e. Involves cytochrome P450 Explanation: b) The addition of glucuronic acid to a drug leads to an increase in its enhances the inactivation and subsequently excretion of the drug. garrow_forward
- The energy requiring stage of glycolysis. * C3 steps 1-3 C6 steps 1-3 C3 steps 4-10 C6 steps 4-10 C4 steps 1-3arrow_forwardWhich of the following functional groups is the most stable to metabolism? a. O b. O c. O d. HO HN upra Me All functional groups are metabolised at the same rate.arrow_forward4. Which of the following is involved in the oxidation of a -CH2-CH2- portion of a substrate to a -CH=CH- bond? a. ATP O b. Coenzyme A Oc. NAD O d. FAD +arrow_forward
- Question 5. The biosynthesis of fatty acids involves an enzyme-catalyzed hydrogenation of an a,ß-unsaturated thioester to the saturated fatty acid intermediate mediated by NADPH+. However, the reverse oxidation reaction during fatty acid metabolism requires a different cofactor FAD. Fatty Acid Biosynthesis a) Draw the structure of FAD. H flocon SCOA H SR + FAD - FADH₂ hydrogenation (reduction) NADPH+, H+ dehydrogenation (oxidation) FAD Fatty Acid Metabolism b) Draw a detailed mechanism of the dehydrogenation of fatty acyl-CoA by FAD (you can abbreviate AD as R). H SRarrow_forward4. A metabolic pathway includes the following condensation reaction. Draw arrow pushing mechanism using B: and/or HA as needed. Draw the final product in the provided box. H3C Haci SCOA SCOA CO2 HSCOAarrow_forwardIdentify the classification of drug metabolism and specific type of reaction involved in each drugsample. Identify the enzyme involved in each reaction.arrow_forward
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