Essential Organic Chemistry, Global Edition
Essential Organic Chemistry, Global Edition
3rd Edition
ISBN: 9781292089034
Author: Paula Yurkanis Bruice
Publisher: PEARSON
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Chapter 18, Problem 44P

(a)

Interpretation Introduction

Interpretation:

Five enzymes required by alpha ketoglutarate that coverts alpha ketoglutarate to succinyl CoA has to be identified.

(b)

Interpretation Introduction

Interpretation:

The proposed mechanism for the reaction should be determined.

Concept introduction:

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1. The enzyme that catalyzes the reversible reaction below requires what cofactor? A. Pyridoxal phosphate B. Paradoxal phosphate C. Tetrahydrofolate D. S-Adenosyl methionine 2. Skeletal muscle exports excess nitrogen to the liver in the form of... A. Alanine B. Tyrosine C. Pyruvate D. Glycine 3. In the urea cycle, ornithine transcarbamoylase condenses a ornithine with what molecule to produce citrulline? A. Carbamate B. Aspartate C. Phosphate D. Carbamoyl phosphate
9. The first two steps of ethanol metabolism are shown below. Which molecule is reduced over the course of these reactions? NAD* NADH+H* NAD* NADH+H* CH3CH2OH CHзCно CHзCOон alcohol ethanol dehydrogenase acetaldehyde acetic acid H20 acetaldehyde dehydrogenase a. ethanol and acetaldehyde b. alcohol dehydrogenase and acetaldehyde dehydrogenase c. ethanol and alcohol dehydrogenase d. acetic acid e. NAD+
Explanation: b) The metabolic pathway of warfarin is deficient since this patient is a Warfarin is partially metabolised, most of it remaining in the bloodstream of warfarin's therapeutic effect. g 5. The addition of glucuronic acid to a drug: a. Decreases its water solubility b. Leads to inactivation of the drug C. c. Is an example of a Phase I metabolism reaction d. Occurs at the same rate in adults and new-borns e. Involves cytochrome P450 Explanation: b) The addition of glucuronic acid to a drug leads to an increase in its enhances the inactivation and subsequently excretion of the drug. g

Chapter 18 Solutions

Essential Organic Chemistry, Global Edition

Ch. 18.7 - Prob. 11PCh. 18.8 - How many conjugated double bonds are there in a....Ch. 18.8 - Instead of adding to the 4a-position and...Ch. 18.8 - In succinate dehydrogenase, FAD is covalently...Ch. 18.8 - Prob. 15PCh. 18.9 - Acetolactate synthase is another TPP-requiring...Ch. 18.9 - Acetolactate synthase can also transfer the acyl...Ch. 18.9 - Prob. 18PCh. 18.9 - Prob. 19PCh. 18.10 - Prob. 21PCh. 18.11 - Prob. 23PCh. 18.11 - Which compound is more easily decarboxylated?Ch. 18.11 - Explain why the ability of PLP to catalyze an...Ch. 18.11 - Explain why the ability of PLP to catalyze an...Ch. 18.12 - What groups are interchanged in the following...Ch. 18.13 - Why is the coenzyme called tetrahydrofolate?Ch. 18.13 - What amino acid is formed by the following...Ch. 18.13 - How do the structures of tetrahydrofolate and...Ch. 18.13 - What is the source of the methyl group in...Ch. 18 - Prob. 32PCh. 18 - Prob. 33PCh. 18 - From what vitamins are the following coenzymes...Ch. 18 - Prob. 35PCh. 18 - For each of the following reaction, name both the...Ch. 18 - Explain why serine proteases do not catalyze...Ch. 18 - Prob. 38PCh. 18 - For each of the following enzyme catalyzed...Ch. 18 - Trisephosphate isomerase (TIM) catalyzes the...Ch. 18 - Prob. 41PCh. 18 - What acyl groups have we seen transferred by...Ch. 18 - When UMP is dissolved in T2O, exchange of T for H...Ch. 18 - Prob. 44PCh. 18 - When transaminated, the three branched-chain amino...Ch. 18 - Aldolase shows no activity if it is incubated with...
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