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Genetic Analysis: An Integrated Approach (2nd Edition)
2nd Edition
ISBN: 9780321948908
Author: Mark F. Sanders, John L. Bowman
Publisher: PEARSON
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Textbook Question
Chapter 18, Problem 10P
Based on the tree of life in Figure
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Ryan has sprained his ankle for the fifth time in the last few years. He believes he is now more prone to spraining it than he used to be. It also takes several weeks for it to feel better, unlike Grace, who twisted her ankle last weekend, but it feels better already. Explain what may be going on here on a molecular level, using the following questions as guidelines:
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Helping tags: biology, cell biology, cell structure, cell organelle
You are a molecular biologist studying a defective human protein that is known to be the cause of a rare cancer. You isolate the suspected protein from a person with this cancer and compare it to the same protein in a person without the cancer. You discover that the protein isolated from the cancer patient is slightly smaller in size when compared to the protein from the unaffected patient. Furthermore, you discover that the protein from the cancer patient differs in almost every amino acid starting after the twenty-third amino acid. What is the likely explanation?
Chapter 18 Solutions
Genetic Analysis: An Integrated Approach (2nd Edition)
Ch. 18 - You have discovered a new species of Archaea from...Ch. 18 - 16.2 Repetitive DNA poses problems for genome...Ch. 18 - 16.3 When the whole-genome shotgun sequence of the...Ch. 18 - How do cDNA sequences facilitate gene annotation?...Ch. 18 - 16.5 How do comparisons between genomes of related...Ch. 18 - 16.6 You are designing algorithms for the...Ch. 18 - 16.7 You have sequenced a region of the Bacillus...Ch. 18 - You have just obtained 100-kb of genomic sequence...Ch. 18 - 16.9 The human genome contains a large number of...Ch. 18 - Based on the tree of life in Figure 16.12, would...
Ch. 18 - 16.11 When comparing genes from two sequenced...Ch. 18 - Prob. 12PCh. 18 - Prob. 13PCh. 18 - Prob. 14PCh. 18 - 16.16 Consider the phylogenetic tree below with...Ch. 18 - You have isolated a gene that is important for the...Ch. 18 - 16.18 When the human genome is examined, the...Ch. 18 - Symbiodinium minutum is a dinoflagellate with a...Ch. 18 - Substantial fractions of the genomes of many...Ch. 18 - 16.21 A modification of the system, called the ...Ch. 18 - 16.22 A substantial fraction of almost every...Ch. 18 - 16.23 In the globin gene family shown in Figure ,...Ch. 18 - You are studying similarities and differences in...Ch. 18 - In conducting the study described in Problem 24,...Ch. 18 - Prob. 26PCh. 18 - Prob. 27PCh. 18 - Prob. 28PCh. 18 - If you were to compare your genome sequence with...
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- You are a molecular biologist studying a defective human protein that is known to be a cause of a rare cancer. You isolate the suspected protein from a person with this cancer and compare it to the same protein in a person without the cancer. You discover that the protein isolated from the cancer patient is slightly smaller in size when compared to the protein from the unaffected patient. Furthermore, you discover that the protein from the cancer patient differs in almost every amino acid starting after the 23rd amino acid. What is the likely explanation?arrow_forwardTo construct an “interactome” like the one shown in Figure 9-21, scientists identify all of the protein interactions in a particular tissue or cell type. Comparison of interactomes from human muscle versus human brain tissue reveals very different patterns. If you were the scientist involved in this study, how would you explain these results?arrow_forwardWhich term among A-D is not correctly matched with its definition? A) O Slime layer: loose assemblage of polysaccharide material external to the cell envelope B) O Polysome or polyribosome formation: multiple ribosomes binding to a messenger RNA transcript C) O Replisome: two of these complexes working in opposite directions are needed to copy the bacterial chromosome D) O Nucleoid: cytoplasmic area containing the bacterial chromosome E) OA-D are all correctly matchedarrow_forward
- A large ear of corn has a total of 4333 grains including 271 purple smooth,73 purple and shrunken, 63 yellow and smooth, and 26 yellow shrunken a) What is the Chi-square value? b) Make a hypothesis.arrow_forwardIf you’re comparing the sequences of protein “R” from multiple vertebrates, arthropods, protists, and bacteria, which PAM or BLOSUM matrix would be the most suitable compared to others? Explain your reasoning.arrow_forwardGene editing is also used to explore the structure and function ofproteins. For example, changes can be made to the coding sequenceof a gene to determine how alterations in the amino acid sequenceaffect the function of a protein. Let’s suppose that you areinterested in the functional importance of a particular glutamicacid (an amino acid) within a protein you are studying. By geneediting, you make mutant proteins in which the glutamic acidcodon has been changed to other codons. You then test the encodedmutant proteins for functionality. The results are as follows: FunctionalityNormal protein 100%Mutant proteins containingTyrosine 5%Phenylalanine 3%Aspartic acid 94%Glycine 4%From these results, what would you conclude about the…arrow_forward
- Insulin is a peptide hormone encoded by the INS gene, which is on chromosome 11. Insulin is produced by pancreatic beta cells. A) Both the INS gene and insulin are examples of biological molecules that are polymers. What are the monomers and what is the polymer that make up the INS gene? What is the name of the monomers and polymer that make up insulin? B). How many copies of the INS gene are found in pancreatic beta cells? How many copies are found in other cell types, for example, cardiac muscle cells? C). Is mRNA for insulin produced in equal amounts in pancreatic beta cells and cardiac muscle cells? Why or why not? D) Diabetes mellitus can be caused by a dominant mutation in the INS gene, INS*C96Y. A healthy mother has an affect child. Give the genotype of the child at the INS locus, indicating the paternally and maternally inherited alleles.arrow_forwardWhy is the One-Gene-One Protein Hypothesis now replaced by the One-Gene-One-Polypeptide Hypothesis?arrow_forwardIn the diagram of DNA at the right: a) fill in the letters representing the bases on the right-hand strand. b) How many nucleotides are shown? 6 c) Explain why these two strands are described as "anti-parallel." because two stands in apposite directions d) If the DNA strand on the left is the coding strand, what mRNA sequence would be transcribed from it? ACG e) What amino acid would that mRNA strand code for? (read the letters from top to bottom) (The) threonine 2' 1' 2 AT बबब GH Carrow_forward
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