Genetic Analysis: An Integrated Approach (2nd Edition)
Genetic Analysis: An Integrated Approach (2nd Edition)
2nd Edition
ISBN: 9780321948908
Author: Mark F. Sanders, John L. Bowman
Publisher: PEARSON
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Chapter 18, Problem 25P

In conducting the study described in Problem 24 , you have noted that a set of S. cerevisiae genes are repressed when yeast are grown under high-salt conditions.

How might you determine whether this set of genes is regulated by a common transcription factor?

How might you approach this question if genome sequences for the related Saccharomyces species, S. paradoxus, S. mikatae, and S. bayanus, were also available?

You are studying similarities and differences in how organisms respond to high salt concentrations and high temperatures. You begin your investigation by using microarrays to compare gene expression patterns of S. cerevisiae in normal growth conditions, in high-salt concentrations, and at high temperatures. The results are shown here with the values of red and green representing the extent of the increase and decrease, respectively, of expression for genes a–s in the experimental conditions versus the control (normal growth) conditions. What is the first step you will take to analyze your data?

Chapter 18, Problem 25P, In conducting the study described in Problem 24, you have noted that a set of S. cerevisiae genes

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The Saccharomyces cerevisiae nuclear gene ARG8encodes an enzyme that catalyzes a key step in biosynthesis of the amino acid arginine. This protein isnormally synthesized on cytoplasmic ribosomes, butthen is transported into mitochondria, where the enzyme conducts its functions. In 1996, T. D. Fox andhis colleagues constructed a strain of yeast in which agene encoding the Arg8 protein was itself moved intomitochondria, where functional protein could besynthesized on mitochondrial ribosomes.a. How could these investigators move the ARG8gene from the nucleus into the mitochondria, whilepermitting the synthesis of active enzyme? In whatways would the investigators need to alter theARG8 gene to allow it to function in the mitochondria instead of in the nucleus?b. Why might these researchers have wished to movethe ARG8 gene into mitochondria in the firstplace?
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Chapter 18 Solutions

Genetic Analysis: An Integrated Approach (2nd Edition)

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