Genetic Analysis: An Integrated Approach (2nd Edition)
2nd Edition
ISBN: 9780321948908
Author: Mark F. Sanders, John L. Bowman
Publisher: PEARSON
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Chapter 18, Problem 4P
How do cDNA sequences facilitate gene annotation?
Describe how the use of
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Outline a mechanism by which RNA can catalyze its own self-splicing.
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Explain briefly why alternative splicing is said to ‘expand the genome.’
Chapter 18 Solutions
Genetic Analysis: An Integrated Approach (2nd Edition)
Ch. 18 - You have discovered a new species of Archaea from...Ch. 18 - 16.2 Repetitive DNA poses problems for genome...Ch. 18 - 16.3 When the whole-genome shotgun sequence of the...Ch. 18 - How do cDNA sequences facilitate gene annotation?...Ch. 18 - 16.5 How do comparisons between genomes of related...Ch. 18 - 16.6 You are designing algorithms for the...Ch. 18 - 16.7 You have sequenced a region of the Bacillus...Ch. 18 - You have just obtained 100-kb of genomic sequence...Ch. 18 - 16.9 The human genome contains a large number of...Ch. 18 - Based on the tree of life in Figure 16.12, would...
Ch. 18 - 16.11 When comparing genes from two sequenced...Ch. 18 - Prob. 12PCh. 18 - Prob. 13PCh. 18 - Prob. 14PCh. 18 - 16.16 Consider the phylogenetic tree below with...Ch. 18 - You have isolated a gene that is important for the...Ch. 18 - 16.18 When the human genome is examined, the...Ch. 18 - Symbiodinium minutum is a dinoflagellate with a...Ch. 18 - Substantial fractions of the genomes of many...Ch. 18 - 16.21 A modification of the system, called the ...Ch. 18 - 16.22 A substantial fraction of almost every...Ch. 18 - 16.23 In the globin gene family shown in Figure ,...Ch. 18 - You are studying similarities and differences in...Ch. 18 - In conducting the study described in Problem 24,...Ch. 18 - Prob. 26PCh. 18 - Prob. 27PCh. 18 - Prob. 28PCh. 18 - If you were to compare your genome sequence with...
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Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Similar questions
- IS. Alternative splicing has been estimated to occur in more than 95% of multi-exon genes. Which of the following is not an evolutionary advantage of alternative splicing? Alternative splicing increases diversity without increasing genome size Different gene isoforms can be expressed in different tissues Alternative splicing creates shorter mRNA transcripts Different gene isoforms can be expressed during different stages of development.arrow_forwardGive examples of structural motifs found in transcription factors that interact with other proteins instead of DNA.arrow_forwardAssume alternative splicing can generate all permutations and combinations. How many proteins could a gene with three exons and two introns generate?arrow_forward
- Suppose you had isolated a new transcription factor and wanted to know which genes this protein might regulate. Is there any way that you could use a cDNA microarray of the type shown in the picture to approach this question?arrow_forwardSuppose that a 20-bp deletion occurs in the middle of exon 2 of the gene. What will be the likely effect of this deletion in the proteins produced by alternative splicing?arrow_forwardWhat is meant by the term self-splicing? What types of introns are self-splicing?arrow_forward
- ATM is a kinase that phosphorylates histone H2AX in response to double-stranded DNA breaks. Which of the following scenarios would most quickly regulate ATM activity in the cell? a) Adding silencing methyl groups to cytosines in the Atm gene b) Modifying the histone code for the Atm gene c) Increasing expression of a miRNA specific for the Atm mRNA d) Activating an E3 ubiquitin ligase specific for the ATM proteinarrow_forwardA gene contains eight sites where alternativesplicing is possible. Assuming that the splicing pattern at each site is independent of that at all other sites, how many splicing products are possible?arrow_forwardUsing the transcription unit diagrammed below, in which exons are represented by blue boxes and introns are represented by the connecting lines. You discover a single base deletion in region E of this DNA sequence. Regarding transcription, this mutation will likely: 1.) Result in an alteration to the mRNA sequence. 2.)Have no effect on transcription or the mRNA sequence 3.)Prevent transcription at the TATAA box 4.) Result in an increase or decrease in the amount of mRNA transcribedarrow_forward
- What is the minimum length of time required for the synthesis by E. coli polymerase of an mRNA encoding a 100- kDa protein?arrow_forwardWhat is the meaning of the term consensus sequence? Give an example. Describe the locations of consensus sequences within bacterial promoters. What are their functions?arrow_forwardRegarding eukaryotic genes, it is correct to state that: a) Distal enhancer-like elements decrease the intensity of gene transcription activation b) Mutations in intronic regions of a gene can alter the levels of its corresponding protein c) They are regulated only by promoter regions, being activated or repressed by the presence of transcription factors d) The junctions of exons and introns are recognized by splicing factors, which guarantee the production of the same mRNA regardless of cell type. e) Activator and repressor proteins bind to the coding region of genes, regulating the intensity of their transcriptionarrow_forward
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