Genetic Analysis: An Integrated Approach (2nd Edition)
2nd Edition
ISBN: 9780321948908
Author: Mark F. Sanders, John L. Bowman
Publisher: PEARSON
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Chapter 18, Problem 22P
A substantial fraction of almost every genome sequenced consists of genes that have no known function and that do not have sequence similarity to any genes with known function.
Describe two approaches to ascertaining the biological role of these genes in S. cerevisiae.
How would your approach change if the genes of unknown function were in the human genome?
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The genome of D. melanogaster consists of approximately 1.7 * 108 base pairs. DNA synthesis occurs at a rate of 30 base pairs per second. In the early embryo, the entire genome is replicated in five minutes. How many bidirectional origins of synthesis are required to accomplish this feat?
A group of scientists sequenced the genomes of 12 species of Drosophila (Drosophila 12 Genomes Consortium. 2007. Nature 450:203–218). Data on genome sizes and numbers of protein-encoding genes from this study are given in the accompanying table. Plot the number of protein-encoding genes as a function of genome size for the 12 species of Drosophila. Is there a relation between genome size and number of genes in fruit flies? How does this compare with the relation between genome size and number of genes across all eukaryotes?
Discuss how ultra violet light works as a mutagen. This could include:
What is UV light and the Mutations commonly introduced by UV light? What are the Repair mechanisms in yeast that fix damage caused by UV light?
Describe the phenotypes of Saccharomyces Cerevisiae plates, the first plate is the control yeast, while the second plate has been exposed to low UV light, the third plate has been exposed to high UV light. Normal yeast has round smooth white colonies. Are there any signinifcant differences?
Chapter 18 Solutions
Genetic Analysis: An Integrated Approach (2nd Edition)
Ch. 18 - You have discovered a new species of Archaea from...Ch. 18 - 16.2 Repetitive DNA poses problems for genome...Ch. 18 - 16.3 When the whole-genome shotgun sequence of the...Ch. 18 - How do cDNA sequences facilitate gene annotation?...Ch. 18 - 16.5 How do comparisons between genomes of related...Ch. 18 - 16.6 You are designing algorithms for the...Ch. 18 - 16.7 You have sequenced a region of the Bacillus...Ch. 18 - You have just obtained 100-kb of genomic sequence...Ch. 18 - 16.9 The human genome contains a large number of...Ch. 18 - Based on the tree of life in Figure 16.12, would...
Ch. 18 - 16.11 When comparing genes from two sequenced...Ch. 18 - Prob. 12PCh. 18 - Prob. 13PCh. 18 - Prob. 14PCh. 18 - 16.16 Consider the phylogenetic tree below with...Ch. 18 - You have isolated a gene that is important for the...Ch. 18 - 16.18 When the human genome is examined, the...Ch. 18 - Symbiodinium minutum is a dinoflagellate with a...Ch. 18 - Substantial fractions of the genomes of many...Ch. 18 - 16.21 A modification of the system, called the ...Ch. 18 - 16.22 A substantial fraction of almost every...Ch. 18 - 16.23 In the globin gene family shown in Figure ,...Ch. 18 - You are studying similarities and differences in...Ch. 18 - In conducting the study described in Problem 24,...Ch. 18 - Prob. 26PCh. 18 - Prob. 27PCh. 18 - Prob. 28PCh. 18 - If you were to compare your genome sequence with...
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- Most organisms display a circadian rhythm, a cycling of biological processes that is roughly synchronized with day length. In Drosophila, pupae eclose (emerge as adults after metamorphosis) at dawn. a)Using this knowledge how would screen for Drosophila mutants that have an impaired circadian rhythm? b)In each case, how would you clone the genes you identified by mutation?arrow_forwardIllustrate about the Map and sequence the genomes of several model organisms used in experimental genetics, including Escherichia coli, Saccharomyces cerevisiae, Caenorhabditis elegans, Drosophila melanogaster, and Mus musculus (mouse).arrow_forwardWhat are some reasons why, in multicellular eukaryotes, genome size is not necessarily related to number of protein-coding genes or organismal complexity?arrow_forward
- What percentage of the DNA sites in yeast are accessible, assuming that the fraction of sites observed for GAL4 is typical? To how many base pairs of the 12-Mb yeast genome does this percentage correspond?arrow_forwardWhat are paralogous and orthologous genes? What are some of the explanations for the finding that humans are a much more complex organism than the roundworm C. elegans, yet have only about 5 percent more protein- coding genes (21,000 versus 20,000)?arrow_forwardThe figure below shows RNA-Seq data (RED) for the D. melanogaster transformer (tra) gene obtained from both adult female and male fruit flies. The blue lines indicate the tra gene structure, with thicker lines indicating exons, and thin lines introns. The 5' end of the gene is on the left, and the 3' end of the gene is on the right. Based on these data, the most likely conclusion is: Males and females express identical isoforms of tra Males express more tra RNA than females The female isoform has fewer amino acids The female isoform has more amino acids The male and female isoforms have different 3'UTRsarrow_forward
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- The period gene of Drosophila melanogaster encodes for a stretch of Thr-Gly repeated in tandem. In natural populations, the three most common alleles encode for 17, 20 and 23 Thr-Gly repeats. The amplification by PCR of the allele encoding for 20 Thr-Gly repeats produces a fragment of 320 bp. Using the same set of primers, what is the size expected when amplifying the 17 Thr-Gly allele? 317 303 314 302 In a certain species of plant loci A, B and C have an additive effect on the colour of the flower. Alleles A, B, and C are dominant and alleles a, b and c are recessive. Knowing that a plant with genotype AAbbCc has a pink flower, which genotype, among the ones listed below, will produce the same phenotype? Aabbcc. aabbcc. AaBbCc. AABBCc. In pea plants, tall (T) is dominant to dwarf (t) and yellow (Y) is dominant to green (y). In a cross of true-breeding tall yellow peas x dwarf green…arrow_forwardBased on the question,give an asnwer Question : Name the scoring matrix “A”. List the advantage(s) of this scoring matrix.arrow_forwardDescribe how you would use replica plating of mutagenized, haploid yeast cells to identify temperature-sensitive (ts) mutations in essential genes needed for yeast growth and survival.arrow_forward
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Genome Annotation, Sequence Conventions and Reading Frames; Author: Loren Launen;https://www.youtube.com/watch?v=MWvYgGyqVys;License: Standard Youtube License