Organic And Biological Chemistry
Organic And Biological Chemistry
7th Edition
ISBN: 9781305081079
Author: STOKER, H. Stephen (howard Stephen)
Publisher: Cengage Learning,
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Concept explainers

Question
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Chapter 15, Problem 15.33EP

(a)

Interpretation Introduction

Interpretation: To determine whether oxaloacetate and α-ketoglutaratecould function as the two reactants in a transamination reaction or not.

Concept introduction: Transamination reaction is a biochemical reaction that involves the transfer of an amino group. In transamination reaction exchange of an amino group from an α-aminoacid with a keto group of an α-ketoacid. There occurs no net loss or gain of amino acid in transamination reaction. The general reaction to illustrate transamination is as follows:

Organic And Biological Chemistry, Chapter 15, Problem 15.33EP , additional homework tip  1

The general structure of an amino acid is:

Organic And Biological Chemistry, Chapter 15, Problem 15.33EP , additional homework tip  2

Here, Ris the side chain which is different for a different amino acid.

An acid containing both carbonyl and carboxyl functional group is known as a keto acid. A general representation of a keto acid is:

Organic And Biological Chemistry, Chapter 15, Problem 15.33EP , additional homework tip  3

(a)

Expert Solution
Check Mark

Answer to Problem 15.33EP

No, oxaloacetate and α-ketoglutaratecannot function as the reactants in a transamination reaction.

Explanation of Solution

α-ketoglutarate is keto acid and its structure is:

Organic And Biological Chemistry, Chapter 15, Problem 15.33EP , additional homework tip  4

Oxaloacetate is a keto acid and its structure is:

Organic And Biological Chemistry, Chapter 15, Problem 15.33EP , additional homework tip  5

The two reactants in transamination reaction are a keto acid and an amino acid. Both oxaloacetate and α-ketoglutarate are keto acids thus they cannot function as reactants in a transamination reaction. For a transamination reaction to take place there must be one amino acid present along with a keto acid.

(b)

Interpretation Introduction

Interpretation: To determine whether glutamate and oxaloacetate could function as the two reactants in a transamination reaction or not.

Concept introduction: Transamination reaction is a biochemical reaction that involves the transfer of an amino group. In transamination reaction exchange of an amino group from an α-aminoacid with a keto group of an α-ketoacid. There occurs no net loss or gain of amino acid in transamination reaction. The general reaction to illustrate transamination is as follows:

Organic And Biological Chemistry, Chapter 15, Problem 15.33EP , additional homework tip  6

The general structure of an amino acid is:

Organic And Biological Chemistry, Chapter 15, Problem 15.33EP , additional homework tip  7

Here, Ris the side chain which is different for a different amino acid.

An acid containing both carbonyl and carboxyl functional group is known as a keto acid. A general representation of a keto acid is:

Organic And Biological Chemistry, Chapter 15, Problem 15.33EP , additional homework tip  8

(b)

Expert Solution
Check Mark

Answer to Problem 15.33EP

Yes, glutamate and oxaloacetate can function as the reactants in a transamination reaction.

Explanation of Solution

Glutamate is an amino acid and its structure is:

Organic And Biological Chemistry, Chapter 15, Problem 15.33EP , additional homework tip  9

Oxaloacetate is a keto acid and its structure is:

Organic And Biological Chemistry, Chapter 15, Problem 15.33EP , additional homework tip  10

Transamination reaction involves the exchange of an amino group from an α-aminoacid with a keto group of an α-ketoacid. The two reactants in transamination reaction are a keto acid and an amino acid. Since oxaloacetate is a keto acid and glutamate is an amino acid they can function as reactants in a transamination reaction.

(c)

Interpretation Introduction

Interpretation: To determine whether glutarate and glutamate could function as the two reactants in a transamination reaction or not.

Concept introduction: Transamination reaction is a biochemical reaction that involves the transfer of an amino group. In transamination reaction exchange of an amino group from an α-aminoacid with a keto group of an α-ketoacid. There occurs no net loss or gain of amino acid in transamination reaction. The general reaction to illustrate transamination is as follows:

Organic And Biological Chemistry, Chapter 15, Problem 15.33EP , additional homework tip  11

The general structure of an amino acid is:

Organic And Biological Chemistry, Chapter 15, Problem 15.33EP , additional homework tip  12

Here, Ris the side chain which is different for a different amino acid.

An acid containing both carbonyl and carboxyl functional group is known as a keto acid. A general representation of a keto acid is:

Organic And Biological Chemistry, Chapter 15, Problem 15.33EP , additional homework tip  13

(c)

Expert Solution
Check Mark

Answer to Problem 15.33EP

No, glutarate and glutamate cannot function as the reactants in a transamination reaction.

Explanation of Solution

Glutarate is a diacid and its structure is:

Organic And Biological Chemistry, Chapter 15, Problem 15.33EP , additional homework tip  14

Glutamate is an amino acid and its structure is:

Organic And Biological Chemistry, Chapter 15, Problem 15.33EP , additional homework tip  15

The two reactants in transamination reaction are a keto acid and an amino acid. Glutamate is an amino acid but glutarate is not a keto acid. For a transamination reaction to take place there must be one keto acid present along with an amino acid. Thus, glutarate and glutamate cannot function as the reactants in a transamination reaction.

(d)

Interpretation Introduction

Interpretation: To determine whether oxaloacetate and succinate could function as the two reactants in a transamination reaction or not.

Concept introduction: Transamination reaction is a biochemical reaction that involves the transfer of an amino group. In transamination reaction exchange of an amino group from an α-aminoacid with a keto group of an α-ketoacid. There occurs no net loss or gain of amino acid in transamination reaction.

The general reaction to illustrate transamination is as follows:

Organic And Biological Chemistry, Chapter 15, Problem 15.33EP , additional homework tip  16

The general structure of an amino acid is:

Organic And Biological Chemistry, Chapter 15, Problem 15.33EP , additional homework tip  17

Here, Ris the side chain which is different for a different amino acid.

An acid containing both carbonyl and carboxyl functional group is known as a keto acid. A general representation of a keto acid is:

Organic And Biological Chemistry, Chapter 15, Problem 15.33EP , additional homework tip  18

(d)

Expert Solution
Check Mark

Answer to Problem 15.33EP

No, oxaloacetate and succinate cannot function as the reactants in a transamination reaction.

Explanation of Solution

Oxaloacetate is a keto acid and its structure is:

Organic And Biological Chemistry, Chapter 15, Problem 15.33EP , additional homework tip  19

Succinate is a diacid acid and its structure is:

Organic And Biological Chemistry, Chapter 15, Problem 15.33EP , additional homework tip  20

The two reactants in transamination reaction are a keto acid and an amino acid. Oxaloacetate is keto acid but succinate is not an amino acid. For a transamination reaction to take place there must be one amino acid present along with a keto acid. Thus, oxaloacetate and succinate cannot function as the reactants in a transamination reaction.

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Chapter 15 Solutions

Organic And Biological Chemistry

Ch. 15.3 - Prob. 4QQCh. 15.3 - Prob. 5QQCh. 15.3 - Prob. 6QQCh. 15.4 - Prob. 1QQCh. 15.4 - Prob. 2QQCh. 15.4 - Prob. 3QQCh. 15.4 - Prob. 4QQCh. 15.4 - Prob. 5QQCh. 15.4 - In the urea cycle, the urea-producing step...Ch. 15.5 - Which of the following statements concerning the...Ch. 15.5 - Prob. 2QQCh. 15.5 - Which of the following statements concerning the...Ch. 15.5 - Prob. 4QQCh. 15.6 - Prob. 1QQCh. 15.6 - Prob. 2QQCh. 15.6 - Prob. 3QQCh. 15.7 - Prob. 1QQCh. 15.7 - Prob. 2QQCh. 15.7 - In the degradation of heme, which of the following...Ch. 15.7 - In the degradation of heme, the iron atom present...Ch. 15.8 - In degradation of the sulfur-containing amino acid...Ch. 15.8 - Prob. 2QQCh. 15.8 - Prob. 3QQCh. 15.8 - Prob. 4QQCh. 15.9 - Prob. 1QQCh. 15.9 - Prob. 2QQCh. 15.9 - Prob. 3QQCh. 15.10 - Transamination reactions require the cofactor PLP...Ch. 15.10 - Prob. 2QQCh. 15.10 - Prob. 3QQCh. 15 - Prob. 15.1EPCh. 15 - Indicate whether each of the following aspects of...Ch. 15 - Prob. 15.3EPCh. 15 - Prob. 15.4EPCh. 15 - Prob. 15.5EPCh. 15 - Prob. 15.6EPCh. 15 - Prob. 15.7EPCh. 15 - Prob. 15.8EPCh. 15 - Prob. 15.9EPCh. 15 - Prob. 15.10EPCh. 15 - Prob. 15.11EPCh. 15 - Prob. 15.12EPCh. 15 - Prob. 15.13EPCh. 15 - Indicate whether each of the following statements...Ch. 15 - Prob. 15.15EPCh. 15 - Prob. 15.16EPCh. 15 - Prob. 15.17EPCh. 15 - What are the four major uses for amino acids...Ch. 15 - With the help of Table 26-1, classify each of the...Ch. 15 - Prob. 15.20EPCh. 15 - Prob. 15.21EPCh. 15 - Prob. 15.22EPCh. 15 - Prob. 15.23EPCh. 15 - Prob. 15.24EPCh. 15 - Prob. 15.25EPCh. 15 - Prob. 15.26EPCh. 15 - Prob. 15.27EPCh. 15 - Prob. 15.28EPCh. 15 - Prob. 15.29EPCh. 15 - Prob. 15.30EPCh. 15 - Prob. 15.31EPCh. 15 - Prob. 15.32EPCh. 15 - Prob. 15.33EPCh. 15 - Prob. 15.34EPCh. 15 - Prob. 15.35EPCh. 15 - Prob. 15.36EPCh. 15 - Prob. 15.37EPCh. 15 - Prob. 15.38EPCh. 15 - Prob. 15.39EPCh. 15 - Prob. 15.40EPCh. 15 - Prob. 15.41EPCh. 15 - Prob. 15.42EPCh. 15 - Draw the structure of the -keto acid produced from...Ch. 15 - Draw the structure of the -keto acid produced from...Ch. 15 - Prob. 15.45EPCh. 15 - Prob. 15.46EPCh. 15 - Prob. 15.47EPCh. 15 - Prob. 15.48EPCh. 15 - Prob. 15.49EPCh. 15 - Prob. 15.50EPCh. 15 - Prob. 15.51EPCh. 15 - Prob. 15.52EPCh. 15 - Prob. 15.53EPCh. 15 - Prob. 15.54EPCh. 15 - What is a carbamoyl group?Ch. 15 - Prob. 15.56EPCh. 15 - Prob. 15.57EPCh. 15 - Prob. 15.58EPCh. 15 - Prob. 15.59EPCh. 15 - Prob. 15.60EPCh. 15 - Prob. 15.61EPCh. 15 - Prob. 15.62EPCh. 15 - Prob. 15.63EPCh. 15 - Prob. 15.64EPCh. 15 - Prob. 15.65EPCh. 15 - Prob. 15.66EPCh. 15 - Prob. 15.67EPCh. 15 - Prob. 15.68EPCh. 15 - Prob. 15.69EPCh. 15 - Prob. 15.70EPCh. 15 - Prob. 15.71EPCh. 15 - Prob. 15.72EPCh. 15 - Prob. 15.73EPCh. 15 - Prob. 15.74EPCh. 15 - Prob. 15.75EPCh. 15 - Prob. 15.76EPCh. 15 - Prob. 15.77EPCh. 15 - Prob. 15.78EPCh. 15 - Prob. 15.79EPCh. 15 - Prob. 15.80EPCh. 15 - Prob. 15.81EPCh. 15 - Prob. 15.82EPCh. 15 - Prob. 15.83EPCh. 15 - Prob. 15.84EPCh. 15 - Prob. 15.85EPCh. 15 - Prob. 15.86EPCh. 15 - Prob. 15.87EPCh. 15 - What is the starting material for the biosynthesis...Ch. 15 - Prob. 15.89EPCh. 15 - Prob. 15.90EPCh. 15 - Prob. 15.91EPCh. 15 - Prob. 15.92EPCh. 15 - Prob. 15.93EPCh. 15 - What are the structural differences between...Ch. 15 - Prob. 15.95EPCh. 15 - Prob. 15.96EPCh. 15 - Which bile pigment is responsible for the yellow...Ch. 15 - Prob. 15.98EPCh. 15 - Prob. 15.99EPCh. 15 - Prob. 15.100EPCh. 15 - Prob. 15.101EPCh. 15 - Prob. 15.102EPCh. 15 - Prob. 15.103EPCh. 15 - Prob. 15.104EPCh. 15 - Prob. 15.105EPCh. 15 - Indicate whether each of the following statements...Ch. 15 - Prob. 15.107EPCh. 15 - Prob. 15.108EPCh. 15 - Prob. 15.109EPCh. 15 - Prob. 15.110EPCh. 15 - Prob. 15.111EPCh. 15 - Prob. 15.112EPCh. 15 - Prob. 15.113EPCh. 15 - Prob. 15.114EPCh. 15 - Prob. 15.115EPCh. 15 - Prob. 15.116EP
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