Biochemistry, The Molecular Basis of Life, 6th Edition
Biochemistry, The Molecular Basis of Life, 6th Edition
6th Edition
ISBN: 9780190259204
Author: Trudy McKee, James R. McKee
Publisher: Oxford University Press
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Chapter 1, Problem 30RQ
Summary Introduction

To review:

The three types of biochemical reactions that involve acyl transfer nucleophilic substitution.

Introduction:

Certain reactionsinvolve a nucleophile attack as well as atransfer of the acyl group. These reactions are called “acyl transfer nucleophilic substitution” reactions. In the case of compounds that are derivatives of carboxylic acid, the acyl group acts as a potential leaving group. This process can be explained using the following reaction:

Biochemistry, The Molecular Basis of Life, 6th Edition, Chapter 1, Problem 30RQ

In this reaction, “X” refers to a group containing a heteroatom, which is attached to the acyl group (therefore, it is called “acyl X group”).

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