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What two 2° structures are highlighted (with the black circle) in this figure? The red amino acid sequence is; WKPKMIGGIGGFIKVRQY. What is the most likely sequence of the circled portion? Explain how you choose this sequence You did a BLAST analysis of your POI's and the following were returned as the first hits. 1DIF HIV-1 PROTEASE, 418Z Protease, 1SP5 Protease, 1XL5 PROTEASE RETROPEPSIN What do the PDB ids; 1DIF, 418Z, 1SP5 represent? Based on the BLAST data what is the likely function of your POI?

What two 2° structures are highlighted (with the black circle) in this figure? The red amino acid sequence is; WKPKMIGGIGGFIKVRQY. What is the most likely sequence of the circled portion? Explain how you choose this sequence You did a BLAST analysis of your POI's and the following were returned as the first hits. 1DIF HIV-1 PROTEASE, 418Z Protease, 1SP5 Protease, 1XL5 PROTEASE RETROPEPSIN What do the PDB ids; 1DIF, 418Z, 1SP5 represent? Based on the BLAST data what is the likely function of your POI?

Biochemistry
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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Introduction You are a HIV researcher and the following questions depict your struggles while developing, designing and interpreting experiments. All the questions will relate to one another but you do not need to do them in order. Each question will have multiple parts and partial credit will be given whenever possible. Make sure to use your book and notes to help understand the question and develop your answers thoroughly. Question 1 Your interest in HIV started with the protein below the protein below. 1HSG is a dimer and is crystalized with a resolution of 1.9A. The active site is made up each dimer with one monomer in blue and the other in red. What two 2° structures are highlighted (with the black circle) in this figure? The red amino acid sequence is; WKPKMIGGIGGFIKVRQY. What is the most likely sequence of the circled portion? Explain how you choose this sequence You did a BLAST analysis of your POI's and the following were returned as the first hits. 1DIF HIV-1 PROTEASE, 418Z Protease, 1SP5 Protease, 1XL5 PROTEASE RETROPEPSIN What do the PDB ids; 1DIF, 418Z, 1SP5 represent? . Based on the BLAST data what is the likely function of your POI?
Transcribed Image Text:Introduction You are a HIV researcher and the following questions depict your struggles while developing, designing and interpreting experiments. All the questions will relate to one another but you do not need to do them in order. Each question will have multiple parts and partial credit will be given whenever possible. Make sure to use your book and notes to help understand the question and develop your answers thoroughly. Question 1 Your interest in HIV started with the protein below the protein below. 1HSG is a dimer and is crystalized with a resolution of 1.9A. The active site is made up each dimer with one monomer in blue and the other in red. What two 2° structures are highlighted (with the black circle) in this figure? The red amino acid sequence is; WKPKMIGGIGGFIKVRQY. What is the most likely sequence of the circled portion? Explain how you choose this sequence You did a BLAST analysis of your POI's and the following were returned as the first hits. 1DIF HIV-1 PROTEASE, 418Z Protease, 1SP5 Protease, 1XL5 PROTEASE RETROPEPSIN What do the PDB ids; 1DIF, 418Z, 1SP5 represent? . Based on the BLAST data what is the likely function of your POI?
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