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sample of the patient's normal tissue. These studies indicate that the normal tissue has one activ two active IGF2 alleles. Which of the following best explains the observed gene dosage results? A) Growth factor alleles are expressed equally unless a mutation is present B) Loss of normal imprinting occurred as part of carcinogenesis in the tumor tissue C) Paternal imprinting is present in the normal tissue and maternal imprinting in the tumor D) The patient is heterozygous for a loss-of-function mutation in the IGF2 allele E) Tumor tissue developed a mutation that caused imprinting of the IGF2 allele

sample of the patient's normal tissue. These studies indicate that the normal tissue has one activ two active IGF2 alleles. Which of the following best explains the observed gene dosage results? A) Growth factor alleles are expressed equally unless a mutation is present B) Loss of normal imprinting occurred as part of carcinogenesis in the tumor tissue C) Paternal imprinting is present in the normal tissue and maternal imprinting in the tumor D) The patient is heterozygous for a loss-of-function mutation in the IGF2 allele E) Tumor tissue developed a mutation that caused imprinting of the IGF2 allele

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A 4-year-old boy is brought to the physician for a well-child examination. Physical examination shows a 5-cm right-sided abdominal mass. Renal ultrasonography shows a right Kidney mass. A right nephrectomy is done and pathology confirms the diagnosis of nephroblastoma (Wilms tumor). Gene expression studies are done on the tumor tissue and a sample of the patient's normal tissue. These studies indicate that the normal tissue has one active allele for the insulin-like growth factor 2 gene (IGF2) and the tumor tissue has two active IGF2 alleles. Which of the following best explains the observed gene dosage results? A) Growth factor alleles are expressed equally unless a mutation is present B) Loss of normal imprinting occurred as part of carcinogenesis in the tumor tissue C) Paternal imprinting is present in the normal tissue and maternal imprinting in the tumor D) The patient is heterozygous for a loss-of-function mutation in the IGF2 allele E) Tumor tissue developed a mutation that caused imprinting of the IGF2 allele
Transcribed Image Text:A 4-year-old boy is brought to the physician for a well-child examination. Physical examination shows a 5-cm right-sided abdominal mass. Renal ultrasonography shows a right Kidney mass. A right nephrectomy is done and pathology confirms the diagnosis of nephroblastoma (Wilms tumor). Gene expression studies are done on the tumor tissue and a sample of the patient's normal tissue. These studies indicate that the normal tissue has one active allele for the insulin-like growth factor 2 gene (IGF2) and the tumor tissue has two active IGF2 alleles. Which of the following best explains the observed gene dosage results? A) Growth factor alleles are expressed equally unless a mutation is present B) Loss of normal imprinting occurred as part of carcinogenesis in the tumor tissue C) Paternal imprinting is present in the normal tissue and maternal imprinting in the tumor D) The patient is heterozygous for a loss-of-function mutation in the IGF2 allele E) Tumor tissue developed a mutation that caused imprinting of the IGF2 allele
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