You have two patients with pancreatic cancer. Patient 1 has a KRAS oncogenic mutation; a myc oncogenic mutation and has normal levels of P53 Patient 2 has normal KRAS expression; a myc oncogenic mutation and a tumor suppressor mutatic in P53. You have the following therapeutics available Flavopiradol (a CDK inhibitor); CBP-93872 (a G2/M checkpoint inhibitor): Rigosertib; Oncorine; Nutlin a. Which patient would CBP-93872 be the most effective? Explain your answer.

Human Anatomy & Physiology (11th Edition)
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You have two patients with pancreatic cancer.
Patient 1 has a KRAS oncogenic mutation; a myc oncogenic mutation and has normal levels of P53.
Patient 2 has normal KRAS expression: a myc oncogenic mutation and a tumor suppressor mutation
in P53.
You have the following therapeutics available
Flavopiradol (a CDK inhibitor); CBP-93872 (a G2/M checkpoint inhibitor); Rigosertib; Oncorine;
Nutlin
a. Which patient would CBP-93872 be the most effective? Explain your answer.
b. Which therapeutic(s) would not be expected to be effective in patient 2? For each, explain your
answer
Transcribed Image Text:You have two patients with pancreatic cancer. Patient 1 has a KRAS oncogenic mutation; a myc oncogenic mutation and has normal levels of P53. Patient 2 has normal KRAS expression: a myc oncogenic mutation and a tumor suppressor mutation in P53. You have the following therapeutics available Flavopiradol (a CDK inhibitor); CBP-93872 (a G2/M checkpoint inhibitor); Rigosertib; Oncorine; Nutlin a. Which patient would CBP-93872 be the most effective? Explain your answer. b. Which therapeutic(s) would not be expected to be effective in patient 2? For each, explain your answer
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