Mutations that eliminate the function of a protein are generally associated with: missense changes in a small number of codons in a gene mutations creating UGA, UAA or UAG sequences in introns base pair changes that occur within the promoter of a gene activating mutations in proto-oncogenes that cause growth mutations in tumor suppressor genes that lead to cancer
Mutations that eliminate the function of a protein are generally associated with:
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missense changes in a small number of codons in a gene |
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mutations creating UGA, UAA or UAG sequences in introns |
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base pair changes that occur within the promoter of a gene |
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activating mutations in proto-oncogenes that cause growth |
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mutations in tumor suppressor genes that lead to cancer |
A scientist is doing a PCR experiment where she is using PCR primers where the 5' ends have a radioactive phosphorus atom (33P) on them. After performing 30 cycles of amplification, where will the radioactivity be found? Assume that the polymerase used has no exonuclease activity.
choose one or more
1-free nucleotides
2-unused primers
3-in the PCR products
When you send your saliva sample to 23andMe, they:
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identify the bases at one of over half a million places in your genome |
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break the DNA using special enzymes and measure the sizes on gels |
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use a special computer and high-power microscope to read the DNA |
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use a microarray technology to sequence all of your chromosomes |
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amplify particular polymorphisms using PCR with an array of primers |
According to guidelines we have to answer first question only. please kindly post the remaining questions separately.
Normal DNA contains a particular sequence of DNA. If the sequence of DNA is changed due to external factors like radiation and internal factors like DNA damage etc. It is called as a mutation.
Sometimes these mutations are not harmful but sometimes these cause dangerous diseases. These mutations are inherited from the parents to the offspring’s.
Missense changes in a small number of codons in a gene, because of this change the final amino acid for the protein is changed, it causes low efficiency of the protein mostly. That is protein is formed correctly but because of the change of the amino acid the protein efficiency is decreased.
So, it is not correct answer
Mutations creating UGA, UAA or UAG sequences in introns. UAA, UAG are the stop codon, this mutation cause the small polypeptides without forming the complete polypeptide which prevents the formation of the protein.
So, it is not correct answer
Base pair changes that occur within the promoter of a gene, promoter is the region from which transcription begins, if this region is mutated then the protein will not be formed.
So, it is not correct answer
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