Lantus differs from "normal" insulin in that:Select one:Oa. The usual insulin molecule has been combined with zinc isophaneOb. A glycine has been substituted in at A21, and two new arginines have been added as B31 and B32*. An aspartic acid has been substituted for proline at B28Od. A "C-peptide" chain has been addedOe The proline at B28 and the lysine at B29 have been reversed

Insulin glargine [GLAR geen], sold under the brand name Lantus is a long-acting insulin. It is…

Answered: Lantus differs from "normal" insulin in…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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Similar questions

Which of the following are true about how pancreatic β cells sense blood glucose levels and release insulin? (select all that apply) Group of answer choices The first step of glycolysis (producing glucose 6-phosphate) is more efficient in pancreatic β cells than in muscle glucose transporters in pancreatic β cells have a higher affinity for glucose than the transporters in other tissues Increased production of ATP is used as a signal that blood glucose is high Insulin is released when blood glucose levels are high Increases in ATP open a K+ channel Influx of Ca2+ stimulates insulin release
Arachidonic (AA) acid is an important lipidinvolved in the production of inflammatorymediators such as prostaglandins. A commontreatment of inflammatory conditions is theadministration of corticosteroids. These drugslower the expression of sPLA2. Describe howcorticosteroid use leads to the lowering ofprostaglandins.
For the mutation of the enzyme, describe the effect it will have on carbohydrate metabolism. Also, make sure to think about the effect it has on muscles versus the liver: Mutation that converted the active site cysteine in glyceraldehyde 3-phosphate dehydrogenase to a serine
For the mutation of the enzyme below, describe the effect it will have on carbohydrate metabolism. Also, make sure to think about the effect it has on muscles versus the liver: Mutation that converted the phosphorylation site serine in fructose 2,6-bisphosphatase to an aspartate. (Hint: aspartate acts as a phosphorylated serine).
1.20-year-old woman with diabetes mellitus was hospitalized with confused consciousness,fever,nausea,vomiting and fruity smelling breath. A urine sample was strongly positive for ketone bodies.Why would an insulin injection decrease her ketone body production? For the answer: a) indicatethe causes of diabetes mellitus:describe the scheme of signal transduction by insulin. b)compare the blood glucose levels in healthy patients and in patients with diabetes mellitus; c)explain why ketone bodies synthesis is activated in this patient: describe the schemes of ketone bodies synthesis and oxidation.
Mrs. Salma, a 55-year-old diabetic patient, experiences slow wound healing and peripheral neuropathy. Investigation reveals alterations in the Pentose Phosphate Pathway. How might dysregulation in the PPP contribute to complications such as slow wound healing and peripheral neuropathy in diabetic patients? Impaired nucleotide synthesis. Elevated insulin sensitivity. Lactic acid accumulation. Reduced oxidative stress.
Because of prolonged stress created by the COVID 19 pandemic, many people have experienced adrenal fatigue created by the General Adaptation Syndrome. Please explain, using COVID-19 as an example, what this is and how this process develops into adrenal fatigue or organ collapse. Be sure to explain each stage of GAS and which/how hormones are involved in your answer.
Hemophilia B, an X-linked genetic disorder which highly affects males, is a condition in which levels of Factor VIII are significantly decreased. Please describe the physiologic pathway which utilizes Factor VIII and describe the consequences of missing this factor from a physiologic perspective.
explain why natural protease inhibitors (peptide extracts from the pancreas of cattle - aprotinin) can also arrest the destruction of pancreatic proteins, but often cause an allergic reaction.
93. In an experiment to determine the effect of the route of administration of glucose on insulin secretion, a healthy 25-year-old man is given oral glucose and an equivalent dose of intravenous glucose on different days. Serum studies show that the insulin concentrations are greater after oral glucose than after intravenous glucose. In comparison with intravenous glucose, oral glucose augments insulin secretion by which of the following actions? A) Decreases secretion of glucagon B) Decreases secretion of somatostatin C) Increases secretion of acetylcholine D) Increases secretion of epinephrine E) Increases secretion of gastrointestinal hormones
For the mutation of the enzyme, describe the effect it will have on carbohydrate metabolism. Also, make sure to think about the effect it has on muscles versus the liver: Mutation that converted the active site glutamate in phosphohexose isomerase to an glutamine.
Acetylcholinesterase converts acetylcholine into acetate and choline . Like serine proteases, acetylcholinesterase is inhibited by DIPF. Propose a catalytic mechanism for acetylcholine digestion by acetylcholinesterase . Show the reaction as chemical structures.

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