Answered: The brain can also use ketone bodies as…

Human Anatomy & Physiology (11th Edition)

11th Edition

ISBN:9780134580999

Author:Elaine N. Marieb, Katja N. Hoehn

Publisher:Elaine N. Marieb, Katja N. Hoehn

Chapter1: The Human Body: An Orientation

Section: Chapter Questions

Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...

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The brain can also use ketone bodies as fuel in addition to utilising glucose when it is present.
Even the use of ketone bodies as a fuel source for the brain rather than glucose is supported by data.
How are ketone bodies used by the brain? Discuss how brain metabolism is thought to be changed in
neurodegenerative diseases(refer to the figure below) How does the brain benefit from using ketone bodies as fuel in these cases(refer to Figure below)

Refer to the article " Effects of Ketone Bodies on Brain Metabolism and Function in Neurodegenerative Diseases" to answer the questions. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7699472/

Figure 2
Neurodegeneration
Glucose
hypometabolism
Ketone oxidation
BHB
Mitochondrial
dysfunction
(2
Energy
Restored deficiency
metabolism
Oxidative stress
Neuroinflammation
Vicious circle of energy crisis in neurodegenerative disease. The proposed effects of beta-hydroxybutyrate (BHB) on disease
mechanisms are illustrated in green, demonstrating an inhibition of oxidative stress, neuroinflammation and mitochondrial
dysfunction together with a facilitated ketone oxidation, which results in at least a partially restored metabolism.

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