Answered: If all of the pentose phosphate pathway…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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Question

If all of the pentose phosphate pathway is functioning (both oxidative and non-oxidative portions), 6 glucose 6-phosphates are used, how many glucose 6-phosphates can be regenerated for use in the liver?

Expert Solution

Pentose Phosphate Pathway

Pentose Phosphate Pathway, also called the HMP shunt pathway is a multipurpose biochemical pathway that takes place in the cytoplasm of all cellular lifeforms. It generates the reducing agent NADPH; provides a way to synthesize and breakdown 3C,4C,5C,6C & 7C sugars and incorporate them into ATP, NADH, FAD, DNA, RNA, Co.A, etc;

The pathway is composed of 2 phases;

Oxidative phase: the oxidative phase can be summed up as,

$G l u c o s e 6 p h o s p h a t e + 2 N A D P^{+} + H_{2} O \to R i b o s e 5 p h o s p h a t e + 2 N A D P H + 2 H^{+} + C O_{2} - - - - (e q 1)$

2. Non-Oxidative phase: the non-oxidative phase can be summed up as,

$3 x (R i b o s e 5 p h o s p h a t e) \to 2 x (F r u c t o s e 6 p h o s p h a t e) + G l y c e r a l d e h y d e 3 p h o s p h a t e - - - - (e q 2)$