Why would glutamate utilize the oxidative deamination pathway over transamination – especially if removal of NH4+ requires ATP? Would it not be favorable for the body to just use transamination

Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
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Why would glutamate utilize the oxidative deamination pathway over transamination – especially if removal of NH4+ requires ATP? Would it not be favorable for the body to just use transamination?  

 

 

 

R
HOANH
Coo
amino acid
various
transaminases
COO
keto-acid
COO
CH₂
CH₂
C=
COO
alpha-ketoglutarate
COO
CH₂
CH₂
HỘ NH
COO
glutamate
Alpha keto
acid
NH4*
NADH
glutamate dehydrogena
NAD*
Alpha amino
acid
Transcribed Image Text:R HOANH Coo amino acid various transaminases COO keto-acid COO CH₂ CH₂ C= COO alpha-ketoglutarate COO CH₂ CH₂ HỘ NH COO glutamate Alpha keto acid NH4* NADH glutamate dehydrogena NAD* Alpha amino acid
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