Holding Potential (mV) Measured Current (pA) -100 -1.0 -50 0.0 0 +1.0 +50 +2.0 +100 +3.0
Patch clamp recording of a single ion channel yields the following results:
|
Holding Potential (mV) |
Measured Current (pA) |
|
-100 |
-1.0 |
|
-50 |
0.0 |
|
0 |
+1.0 |
|
+50 |
+2.0 |
|
+100 |
+3.0 |
part a.) Calculate the membrane potential at the instant when a neuron has the following relative permeabilities: PK+ = 1.0, PNa+ = 1.0, PCl- = 1.0. Use the ionic concentration values in the picture included.
a.) -12 mv
b.) -35mv
c.) -60 mv
d.) +20 mv
e.) 0 mv
part b.) What would be the equilibrium potential for K+ in neurons under such circumstances?
a.) -11 mv
b.) +30 mv
c.) +75 mv
d.) -35 mv
e.) 0 mv
part c.)
What would be the new resting potential, discounting the effects of non-gated chloride channels (just give an approximate value – no calculation is necessary)?
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