Resting membrane potential (assume the following initial conditions; EK = -81 mV, ENa = 58 mV, b = 0.02) Question 9 options: a. If the Na+, K+-ATPase pump was poisoned and ceased working, the membrane potential would gradually become less negative. b. If the extracellular concentration of K+ increased, the membrane potential would depolarize. c. If the intracellular concentration of Na+ doubled, the permeability of the membrane to Na+ would decrease. d. Both a) and b) are correct and c) is incorrect e. Statements a), b) and c) are all correct

Resting membrane potential (assume the following initial conditions; EK = -81 mV, ENa = 58 mV, b = 0.02) Question 9 options: a. If the Na+, K+-ATPase pump was poisoned and ceased working, the membrane potential would gradually become less negative. b. If the extracellular concentration of K+ increased, the membrane potential would depolarize. c. If the intracellular concentration of Na+ doubled, the permeability of the membrane to Na+ would decrease. d. Both a) and b) are correct and c) is incorrect e. Statements a), b) and c) are all correct

Human Physiology: From Cells to Systems (MindTap Course List)

9th Edition

ISBN:9781285866932

Author:Lauralee Sherwood

Publisher:Lauralee Sherwood

Chapter4: Principles Of Neural And Hormonal Communication

Section: Chapter Questions

Problem 3SQE

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Intracellular potentials are on the order of -100mV, whereas extracellular potentials are OmV. Assuming these values, answer the following questions. (a) What is the electric potential energy of a chloride ion (CI-) inside a cell? (b) What about outside the cell? (c) What is the probability of finding a Cl- inside the cell relative to finding it outside the cell? Assume that T=310K. P(inside) P(outside) (d) If the concentration of Cl- outside the cell is 100mM, what is the expected concentration inside the cell?
Calculate the free energy of transport for the movement of potassium by the sodium/potassium pump under normal physiological conditions: 4 mM serum potassium, 135 mM intracellular potassium, 37.1 °C, and resting potential -82 mV. Express your answer in kJ/mol. Show all work. Calculate the free energy of transport for the movement of potassium by the sodium/potassium pump under disturbed conditions of 2 mM serum potassium. Assume all other parameters remain the same. Express your answer in kJ/mol. Show all work. What factors could limit the continued action of the sodium/potassium pump when only 2 mM potassium is present in the blood plasma? Note that under normal physiological conditions, the cell interior contains 11 mM sodium and the blood contains 140 mM sodium.
Define resting membrane potential and describe its electrochemical basis. Briefly discuss changes to resting membrane potential. Provide specific examples of how the 4 essential concepts relative to resting membrane potential or disruption of resting membrane potential.
Calculate the equilibrium membrane potentials to be expected across a membrane at 37 ∘C, with a NaCl concentration of 0.50M on the "right side" and 0.08 M on the "left side", given the following conditions. In each case, state which side is (+) and which is (−). (a)Membrane permeable only to Na+.
Calculate the equilibrium membrane potentials to be expected across a membrane at 37 °C, with a NaCl concentration of 0.10 M on the “right side” and 0.01 M on the “left side”, given the following conditions. In each case, state which side is (+) and which is (-). (a) Membrane permeable only to Na+ (b) Membrane permeable only to Cl– (c) Membrane equally permeable to both ions
Given that the extracellular concentration of Cl- is approximately 120 mM, what is the intracellular concentration if the Nernst potential for Cl- is 39 mV. (T=298 K, R=1.987 cal/K·mol, F=23,062 cal/mol·V)
Calculate the equilibrium membrane potentials to be expected across a membrane at 37 ∘C, with a NaCl concentration of 0.50 M on the "right side" and 0.08 M on the "left side", given the following conditions. In each case, state which side is (+) and which is (−). Membrane equally permeable to both ions.
What is the emf of a cell consisting of a Pb2+/Pb half-cell and a Pt/ H / H₂ half-cell if [Pb2+]=0.87 M, [H+]=0.011 M and Pы, = 1.0 atm? Round your answer to 2 significant digits. Note: Reference the Standard reduction potentials at 25 °C table for additional information. H₂ V X 5
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What is the intracellular voltage for Cl- if the intracellular concentration was 5 mM and the extracellular concentration was 130 mM. Write the voltage as a number in mV inside the cell relative to that outside, eg. -72 or + 90. Question 2. What is the intracellular voltage for Ca++ if the intracellular concentration was 0.0008 mM and the extracellular concentration was 0.6 mM. Write the voltage as a number in mV inside the cell relative to that outside, eg. -72 or +90. Round to the nearest milli Volt.
Nernst (equilibrium) Potential (mV) - 6.lol 0.07 0.125 D.094 lon Intracellular Extracellular Concentration (mM) Concentration (mM) K* 155 4 Nat 12 145 Ca** 104 1.5 4 120 D) If during the generation of an action potential in the skeletal muscle cell the membrane potential approaches +65 mV, membrane permeability for which ion likely plays a major role in membrane depolarization? Explain your choice.
Table Q1(a) shows typical values for the intracellular and extracellular concentrations of the major ion species (in millimoles per litre) for frog skeletal muscle. Table Q1(a) Permeability (cm/s) 2 x 10-8 2х 10 Ions Intracellular Extracellular Na* 12 145 K+ 155 4 4 120 4 x 106 By referring to Table Q1(a), compute the equilibrium resting potential for this membrane by assuming the room temperature is 20° C. Given the Boltzman's constant, k = 1.38 x 1023 J/K and an electronic charge, q = 1.602 x 10-19 C.

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	a. If the Na⁺, K⁺-ATPase pump was poisoned and ceased working, the membrane potential would gradually become less negative.
	b. If the extracellular concentration of K+ increased, the membrane potential would depolarize.
	c. If the intracellular concentration of Na+ doubled, the permeability of the membrane to Na+ would decrease.
	d. Both a) and b) are correct and c) is incorrect
	e. Statements a), b) and c) are all correct