In a resting excitable cell, the membrane is always slightly leaky to K*, because it has a small population of continuously open K* channels. To a far lesser extent, the membrane is also always slightly leaky to Na*. The membrane is typically impermeable to A. Therefore, the membrane potential of a resting excitable cell is a weighted (or skewed) average of EK and ENa EK and EA ENa and EA

Human Anatomy & Physiology (11th Edition)
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Chapter1: The Human Body: An Orientation
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Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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The membrane potential of a cell at any given point is given by the following formula, where the symbol EA denotes the equilibrium potential of A and the fraction A permeability/Total ion
permeability denotes the relative permeability of the membrane to A. (The same definition can be applied to Na+ and K+ .)
Membranepotential
EA
=
Na permeability
Totalionpermeability
X ENa +
K+permeability
Totalionpermeability
x Εκ
A permeability
Totalionpermeability
x EA
In a resting excitable cell, the membrane is always slightly leaky to K+*, because it has a small population of continuously open K+ channels. To a far lesser extent, the membrane is also
always slightly leaky to Nat. The membrane is typically impermeable to A™.
Therefore, the membrane potential of a resting excitable cell is a weighted (or skewed) average of
This baseline value is referred to as the resting potential. A typical resting potential is around
EK and ENa
EK and EA
ENa and EA
-70 mV
Transcribed Image Text:The membrane potential of a cell at any given point is given by the following formula, where the symbol EA denotes the equilibrium potential of A and the fraction A permeability/Total ion permeability denotes the relative permeability of the membrane to A. (The same definition can be applied to Na+ and K+ .) Membranepotential EA = Na permeability Totalionpermeability X ENa + K+permeability Totalionpermeability x Εκ A permeability Totalionpermeability x EA In a resting excitable cell, the membrane is always slightly leaky to K+*, because it has a small population of continuously open K+ channels. To a far lesser extent, the membrane is also always slightly leaky to Nat. The membrane is typically impermeable to A™. Therefore, the membrane potential of a resting excitable cell is a weighted (or skewed) average of This baseline value is referred to as the resting potential. A typical resting potential is around EK and ENa EK and EA ENa and EA -70 mV
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