Given the active site and reaction mechanism below, what is the mechanism of irreversible inhibition of the inhibitor provided? Active Site Reaction Mechanism Inhibitor `NH OH ....o H OH -OH OH -OH NH NNH OH + -Mg+ HO Mg²+ OH

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Given the active site and reaction mechanism below, what is the mechanism of
irreversible inhibition of the inhibitor provided?
Active Site
Reaction Mechanism
Inhibitor
`NH2.
н Он
SH
OH-
OH
OH
HO-
NH
„NH
OH
OH
OH
-Mg²+
Uncompetitive
Affinity-based
Transition state analog
Non-specific
Mechanism-based
Transcribed Image Text:Given the active site and reaction mechanism below, what is the mechanism of irreversible inhibition of the inhibitor provided? Active Site Reaction Mechanism Inhibitor `NH2. н Он SH OH- OH OH HO- NH „NH OH OH OH -Mg²+ Uncompetitive Affinity-based Transition state analog Non-specific Mechanism-based
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