Draw me the inhibition reaction mechanism of Cysteine Protease Inhibitor (E64). How the epoxide ring is opening because of the reaction with the thiol group of cysteine and what product are being made. Please draw with arrow pushing and also explain the reason of each attack.

Human Heredity: Principles and Issues (MindTap Course List)
11th Edition
ISBN:9781305251052
Author:Michael Cummings
Publisher:Michael Cummings
Chapter10: From Proteins To Phenotypes
Section: Chapter Questions
Problem 14QP: If phenylalanine was not an essential amino acid, would diet therapy (the elimination of...
icon
Related questions
icon
Concept explainers
Question

Draw me the inhibition reaction mechanism of Cysteine Protease Inhibitor (E64). How the epoxide ring is opening because of the reaction with the thiol group of cysteine and what product are being made. Please draw with arrow pushing and also explain the reason of each attack.

HO
H₂N
NH
ZI
Cysteine Protease
Inhibitor (E64)
NH
Transcribed Image Text:HO H₂N NH ZI Cysteine Protease Inhibitor (E64) NH
Expert Solution
steps

Step by step

Solved in 3 steps with 2 images

Blurred answer
Knowledge Booster
Macromolecules
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biochemistry and related others by exploring similar questions and additional content below.
Similar questions
  • SEE MORE QUESTIONS
Recommended textbooks for you
Human Heredity: Principles and Issues (MindTap Co…
Human Heredity: Principles and Issues (MindTap Co…
Biology
ISBN:
9781305251052
Author:
Michael Cummings
Publisher:
Cengage Learning
Anatomy & Physiology
Anatomy & Physiology
Biology
ISBN:
9781938168130
Author:
Kelly A. Young, James A. Wise, Peter DeSaix, Dean H. Kruse, Brandon Poe, Eddie Johnson, Jody E. Johnson, Oksana Korol, J. Gordon Betts, Mark Womble
Publisher:
OpenStax College
Basic Clinical Laboratory Techniques 6E
Basic Clinical Laboratory Techniques 6E
Biology
ISBN:
9781133893943
Author:
ESTRIDGE
Publisher:
Cengage
Biology 2e
Biology 2e
Biology
ISBN:
9781947172517
Author:
Matthew Douglas, Jung Choi, Mary Ann Clark
Publisher:
OpenStax