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1 Active Site Reaction Mechanism Inhibitor HN- 2•Zn NH2 HO. HO, NH2 N N- NH `NH NH NH, N' 'N N 'N NH2 OH -OH OH -OH но. HO но- но. он он OH Он 'N' OH но. OH Affinity-based Transition state analog Mechanism-based Uncompetitive

1 Active Site Reaction Mechanism Inhibitor HN- 2•Zn NH2 HO. HO, NH2 N N- NH `NH NH NH, N' 'N N 'N NH2 OH -OH OH -OH но. HO но- но. он он OH Он 'N' OH но. OH Affinity-based Transition state analog Mechanism-based Uncompetitive

Biochemistry
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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mark the mechanism of irreversible inhibition 

1 Active Site Reaction Mechanism Inhibitor HN- 2+Zn NH2 но, HO NH2 N- N. N- N- NH o-H NH NH3 NH N° N. 'N' 'N' NH2 OH OH OH -OH- но но но. HO N- OH OH OH OH OH OH но. OH Affinity-based Transition state analog Mechanism-based Uncompetitive Non-specific
Transcribed Image Text:1 Active Site Reaction Mechanism Inhibitor HN- 2+Zn NH2 но, HO NH2 N- N. N- N- NH o-H NH NH3 NH N° N. 'N' 'N' NH2 OH OH OH -OH- но но но. HO N- OH OH OH OH OH OH но. OH Affinity-based Transition state analog Mechanism-based Uncompetitive Non-specific
2 Active Site Reaction Mechanism Inhibitor `NH2 н он SH OH OH OH -OH O. --N. NH + NH OH OH `O----Mg²+ OH -Mg²+ Uncompetitive Affinity-based Transition state analog Non-specific Mechanism-based
Transcribed Image Text:2 Active Site Reaction Mechanism Inhibitor `NH2 н он SH OH OH OH -OH O. --N. NH + NH OH OH `O----Mg²+ OH -Mg²+ Uncompetitive Affinity-based Transition state analog Non-specific Mechanism-based
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